Biologically active substances that can be involved in the pharmacological reactions of food intolerance. Known histamine releasers are lectins, present in certain legumes, fruits, and oat. Furthermore, foodstuffs like chocolate, strawberries, tomato, fish, eggs, pineapple, ethanol, and meat have been reported to cause histamine release. Symptoms following non-immunoglobulin E-mediated histamine release resemble allergic symptoms.