Frontofacionasal dysplasia (FFND) is characterized by severe abnormalities of the skull and face. Symptoms include facial asymmetry, coloboma of the iris and retina, malformation of the eyelids, narrowing of the palpebral fissures, ocular hypertelorism, telecanthus, limbic dermoid of the eye, midface hypoplasia, anomalies of the corpus callosum, cleft lip and palate, deformed nostrils, and multiple skin appendages. FFND also may be referred to as facio-frontonasal dysplasia, frontofacionasal dysostosis, or nasal- fronto-faciodysplasia; related syndromes include oculoauriculofrontonasal spectrum and frontonasal dysplasia.