A developmental abnormality in which changes occur in bony tissue, resulting in aching and a tendency to pathological fracture. In monostotic fibrous dysplasia one bone is affected; polyostotic fibrous dysplasia involves many bones.
A rare disease in which areas of bone are replaced by fibrous tissue, rendering the bone fragile and liable to fracture. It may involve only one bone usually the thigh bone or femur or several bones. This latter presentation of the disease may be accompanied by pigmentation of the skin and the early onset of puberty.
A rare, nonheritable, congenital bone disease characterized by disorganized alignment of collagen within bone and weak bone formation. Symptoms include bone pain, bone deformities, fractures, and neurological deficits. Some patients are also affected by endocrine disorders, such as diabetes mellitus, acromegaly, or hyperprolactinemia. There are two forms of the disease: monostotic fibrous dysplasia is a variant of the disease in which a single bony lesion is found; in polyostotic fibrous dysplasia, lesions are found in multiple bones, including long bones, facial and cranial bones, or other locations.