A very rare form of hepatitis following exposure to halothane during anaesthesia (1:35,000 halothane anaesthetics). Jaundice develops three to four days after exposure and will occasionally develop into a fatal massive hepatic necrosis. It is of unknown cause but probably has an immunological basis. It is more common following multiple exposures in a short time (less than 28 days), and in obesity, middle age and females. It is rare in children.