An immune response to an organism’s own tissues or components.
An immune response resulting in the presence of self-antigens or autoantigens on the surface of certain body cells; may result in allergy or autoimmune disease.
A condition in which a person’s own cells are attacked by autoantibodies.
The destruction of self through the development of antibodies to the body’s own proteins. It is the result of a loss in antigen recognition specificity. The body produces antibodies to closely related proteins. A number of diseases are thought to be autoimmune diseases. These include thyroiditis, autoimmune type 1 diabetes mellitus, psoriasis, rheumatoid arthritis, and lupus.
Production of antibodies against the tissues of one’s own body, producing autoimmune disease or hypersensitivity reactions.
A condition that occurs when a patient’s antibodies attack his or her own body proteins.
A disorder of the body’s defense mechanisms in which antibodies (autoantibodies) are produced against certain components or products of its own tissues, treating them as foreign material and attacking them.
Autoimmunity is a reaction to an individual’s own tissues (self-antigens) to which tolerance has been lost. Autoantibodies are not necessarily harmful and are commonly encountered in healthy persons. Autoimmune disease ensues when the immune system attacks the target cells of the autoimmune reaction.
The body’s tolerance of the antigens present on its own cells (i.e., self- or autoantigens). It is theorized that self-reactive T lymphocytes (those with receptors that react to self-antigens) are destroyed in the thymus by negative selection or in peripheral blood. Self-reactive T cells that escape destruction in the thymus may become tolerant because they are exposed to thousands of self-antigens as they circulate in the blood.
A medical condition in which the immune system of the body generates antibodies against its own tissues or blood constituents instead of targeting foreign particles or microorganisms.