A condition in which the skull grows tall and the lower part of the face is underdeveloped.
Apert syndrome is a genetic defect that is classified as a craniofacial and limb anomaly. It can be either inherited or sporadically occurring. Apert is one offour autosomal dominant disorders and is a result of de novo mutations. It results in specific distortions of the head, face, hands, and feet during fetal development, including abnormal skull development (craniosynostosis), concave face (midface hypoplasia), and fusion of the fingers and toes (syndactyly). The presence of syndactyly separates Apert syndrome from other similar syndromes.
A congenital condition marked by premature closure of the sutures of the skull causing malformations of the head. Other manifestations include webbed fingers and toes, cleft palate or uvula, prognathic mandible, and maxillary hypoplasia, resulting in extreme malocclusion.