Refers to any compound that works to prevent angiogenesis (formation/development of new blood vessels). Because angiogenesis is required for malignant tumors to grow and/or metastasize (spread), antiangiogenesis was proposed as a means to combat cancer, by Judah Folkman in 1970. Because angiogenesis is required for embryonic development, anti-angiogenic drugs inhibit proper development/growth of infants in the womb. Drugs that have been found to possess antiangiogenic properties include fumagillin, ovalicin, and Thalidomide.
The blocking of the formation of new blood vessels, especially the blood vessels that grow under the influence of malignant tumors. Numerous agents have such activity, including angiostatin, endostatin, tetracyclines, and paclitaxel, among others. They are useful in the treatment of cancer.