An autoimmune disease of the bone marrow.
A form of anemia in which the bone marrow fails to produce adequate numbers of red blood cells.
There are various types of anemias that differ in severity and etiology (e.g., aplastic, sickle cell, and Fanconi). In general, aplastic anemia is the failure of bone marrow to reproduce new blood cells. Specifically, there is a low production of (a) red blood that carries the oxygen to all parts of the body, (b) white blood cells that help the body fight off infection, and (c) platelets that involve the controlling of bleeding by forming blood clots. Production of new blood is of critical importance because blood cells have very limited life spans (e.g., red about 120 days, platelets about 6 days, and white less than 24 hours). The diagnosis of aplastic anemia is usually done through blood and bone marrow tests, and as blood count decreases, severity and morbidity increase.
Deficiency of the formed elements (e.g., red blood cells, white blood cells) of the blood due to a failure of the cell-producing machinery of the bone marrow, caused by a neoplasm or, most commonly, by exposure to toxic chemicals, radiation, or certain drugs.
Deficiency of blood cells resulting from failure of the bone marrow to produce adequate numbers of circulating blood cells; may be congenital or acquired.
A form of anemia that results from bone marrow damage or destruction. Bleeding from various parts of the body and frequent infections occur with this disorder.
A disease in which the bone marrow fails to produce all types of mature blood cells in sufficient numbers. In addition to the symptoms commonly associated with anemia, aplastic anemia can lead to leukopenia (low white blood cell count), which increases the risk of infection, and thrombocytopenia (low platelet count), which results in bleeding from the skin and the mucous membranes, such as those of the nose and gums, and causes easy bruising. Aplastic anemia may be acute or chronic, and it is always progressive, becoming worse over time. Left untreated, the disease leads to death.
Within the realm of medical conditions, a disorder arises in which the human body fails to produce sufficient quantities of red blood cells and hemoglobin. This inadequacy is primarily attributed to underdeveloped or absent bone marrow, the vital tissue responsible for their production. As a result, individuals affected by this condition experience a notable deficiency in their blood’s oxygen-carrying capacity, leading to various symptoms and complications.