Apolipoprotein E (APOE)

The apolipoprotein found on intermediate density lipoprotein and chylomicron that binds to a specific receptor on liver and peripheral cells.


A protein that regulates lipid concentrations in plasma and may repair neuronal damage in the central nervous system. ApoE4 allele is associated with familial late-onset Alzheimer’s disease, possibly because it protects neurons less effectively than other ApoE alleles.


A specific type of protein responsible for conveying cholesterol across various parts of the body. A particular variant of this protein, known as APOE e4, is linked to a heightened probability, approximately 60%, of developing late-onset Alzheimer’s disease.


 


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