Ceramic material that stimulates or otherwise promotes biologic activity. It consists of silicophosphate chains that bond ionically to compounds such as CaO, CaF2, Na2O, ZnO, TiO2, and NiO, among others. It may undergo ionic translocations in vivo, or exchange ions or molecular groups in an osseous recipient site, and thereby osseointegrate. Bioactive glass may be resorbable and is useful as a delivery system in bone engineering.