Category: O

Autografts, treated allografts, and bone substitutes that provide a scaffold for osteoid formation.  

The quality of a graft material which allows it to serve as a scaffold for deposition of osteoid.  

Bone growth by apposition from the surrounding bone. Process by which a material provides scaffolding along which bone growth can occur.  

Mechanism of osteoclast generation through differentiation of precursor cells of the hematopoietic lineage induced by regulatory molecules. Calcitropic factors, such as vitamin D3, prostaglandin E2, interleukin‐1, interleukin‐2, tumor necrosis factor, and glucocorticoid induce receptor activator nuclear factor‐kappa ligand (RANKL) expression on osteoblasts. RANKL binding to the RANK expressed on hematopoietic progenitors activates a signal transduction…

A bone‐specific protein produced by the osteoblast which may play a role in osteoclast recruitment, found in the extracellular matrix of bone, dentin, and the serum of circulating blood. A marker for bone remodeling or mineralization. This vitamin K‐dependent, calcium‐binding protein is produced by osteoblasts and is the most abundant noncollagen protein in bone. Because…

Secreted by mononucleated differentiated cells arising from mesenchymal progenitors and associated with the production of bone by secreting bone matrix and enzymes that facilitate mineral deposition within osteoid matrices.  

A fully differentiated cell that functions in the formation of bone tissue. Osteoblasts synthesize the collagen and glycoproteins that form the bone matrix, and also produce inorganic salts. With growth, they develop into osteocytes. A mononucleate cell that is responsible for bone formation. An immature bone-producing cell. Bone cells that cause the deposition of bone…

Degenerative joint disease. Chronic degeneration and destruction of the articular cartilage and/or fibrous connective tissue linings of the joint components and disks, leading to bony spurs, pain, stiffness, limitation of movement, and changes in bone morphology. Advanced conditions may involve erosions and disk degeneration with crepitus. Is the deterioration of the joints that becomes more…

A bone disease of unknown cause, characterized by enlargement of the cranial bones and often the maxilla or mandible. Radiographically there may be a cotton‐wool appearance. Also known as Paget’s disease. A disease which gradually softens bones in the spine, legs and skull, so that they become curved.  

Inflammation of bone involving the Haversian spaces, canals, and their branches. Inflammation of a bone due to injury or infection. Inflammation of a bone, caused by trauma, degeneration, or infection. Inflammation of bone, due to infection, damage, or metabolic disorder. Osteitis fibrosa cystica refers to the characteristic cystic changes that occur in bones during longstanding…