Collagenase

A metalloproteinase that catalyzes the breakdown of collagen, a key component of the extracellular matrix. It is also responsible for the cleavage of procollagen, which is secreted by the cell during the normal process of collagen production.


Enzymes that break the peptide bonds in collagen.


An enzyme that catalyzes the cleavage of collagen. One example of this is when bacteria in the mouth cause production of collagenase that then cleaves (i.e., breaks down) the collagen that holds teeth in place. Some cancers use collagenase to break down connective tissues in the body they inhabit, to enable the cancers to form the (new) blood vessels that nourish those cancers and help those cancers to spread through the body. Collagenase may also be responsible indirectly for certain autoimmune diseases such as arthritis, via breaking down the protective proteoglycan coat that covers cartilage in the body.


Enzyme that dissolves (lyses) the connective tissue protein collagen.


A member of the metalloproteinase family of enzymes that degrades collagen.


 


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