Abnormal protein that separates from a solution (precipitates), such as blood, when cooled and dissolves when reheated to body temperature. Cryoglobulins are found in the blood in conjunction with certain tumors, as well as some types of pneumonia.
Immunoglobulins that precipitate only in cold temperatures; found mainly in the presence of blood vessel illness.
An abnormal protein, and immunoglobulin, that may be present in the blood in certain diseases. Cryoglobulins become insoluble at low temperatures, leading to obstruction of small blood vessels in the fingers am toes in cold weather and producing; characteristic rash. The presence of cryoglobulins (cryoglobulinemia) may be a feature of a variety of diseases, including macroglobulinemia, systemic lupus erythematosus, and certain infections.
An abnormal globulin that precipitates when cooled and dissolves when reheated to body temperature. Cryoglobulins are usually composed of IgM, or less commonly IgE or IgA molecules. They may form in response to some viral infections, especially to chronic infection by hepatitis C virus.
Within the domain of various diseases, there exists an abnormal blood protein that exhibits a unique property of aggregating and forming clumps when exposed to cold temperatures.