The phenomenon of killing so many infectious organisms so quickly that the amount of dead biomass itself causes liver overload, allergic reactions, or a mild foreign-body response. It can occur with antibiotic therapy, treatment of candidiasis, and even with use of some herbal antivirals. Outside of prescription antifungals, it is seldom acknowledged as a medical problem. If you use a liver stimulant, diaphoretic, and diuretic, you will increase the efficiency of transport, catabolism, and excretion, and lessen the effects of die-off.