A condition with recurrent attacks of fever and pain.
Familial Mediterranean fever (FMF) is a relatively common (in certain ethnic groups) inherited disorder of the immune system. It is classified as one of several rheumatic diseases that are characterized by an altered immune response that causes inflammation in specific organs.
An autosomal recessive disorder in which patients suffer repeated febrile illnesses without evidence of infection. It occurs most often in people of Middle Eastern or Italian descent. Symptomatic attacks typically begin at around ages 5 to 15, often consisting of fever, joint pains, abdominal pain resembling peritonitis, pleurisy or pericarditis, and rashes (although individual symptoms may vary). Duration and frequency of the attacks can be unpredictable. About 40% of patients ultimately develop amyloidosis.
Familial Mediterranean Fever is a genetic disorder predominantly observed in specific ethnic groups such as Sephardic Jews, Armenians, and Arab families. The underlying cause of this condition remains unidentified. Symptoms typically start to manifest between the ages of five and 15, characterized by recurring bouts of fever, stomach and chest discomfort, arthritis, and occasional skin inflammation presenting as red swellings. Some individuals may also experience psychiatric issues. These episodes generally last between 24 to 48 hours, possibly longer. However, it’s noteworthy that there are usually no symptoms in between these attacks.
While there’s no targeted treatment for Familial Mediterranean Fever, people diagnosed with the disorder can lessen the frequency of attacks by using colchicine, a medication typically prescribed for gout. Nevertheless, the condition may ultimately lead to death due to amyloidosis, a serious complication associated with this disorder.