Following injury to, or inflammation of, the pancreas, the fat-splitting enzyme in it may escape into the abdominal cavity, causing death of fat-containing cells.
Destruction or dissolution of fatty tissues, as seen, for example, in patients with severe cases of pancreatitis.
Necrosis occurring in the adipose tissues surrounding the pancreas, resulting from acute destructive pancreatic disease and instigated by the release of pancreatic enzymes that target fat.