A genetic disease almost exclusively of males, which interferes with blood coagulation, resulting in the person bleeding excessively when injured.
Blood lacks a clotting factor.
A group of disorders in which the blood fails to clot properly, usually because of deficiency or total lack of one or more enzymes, called coagulation factors, needed for proper clotting. These are called bleeding disorders, because the dominant characteristic is that blood fails to clot and so keeps on flowing, from external cuts as well as internally, with blood often gathering painfully in the knee and elbow joints. The disorders are identified as a result of various blood tests, such as prothrombin time.
Inherited disorder characterized by excessive bleeding and occurring only in males. Several forms of the disease, including hemophilia A and hemophilia B (also called Christmas disease), occur; in all forms one of the blood clotting factors necessary for normal blood coagulation is missing or present in abnormally low amounts. Greater than usual blood loss in dental extractions and simple injuries, and bleeding into joint areas, commonly occur; severe internal hemorrhage is less common. Treatment involves administration of missing blood coagulation factors (clotting factors) in some cases and transfusions to replace lost blood.
An inherited genetic abnormality of a gene on the X chromosome, causing a lack or a deficiency of a specific clotting factor; disorder causes permanent tendency toward spontaneous and traumatic episodes of hemorrhage.
A hereditary illness in which the blood does not clot, or does so very slowly, predisposing the victim to spontaneous bleeding or prolonged bleeding following trauma or surgery.
An inherited disorder that causes the blood to clot ineffectively and can result in extensive bruising and bleeding. Because of the way in which it is inherited, hemophilia affects males almost exclusively. Individuals with hemophilia used to die at a young age, but with current treatments, the life span is nearly normal.
A hereditary disorder in which the blood clots very slowly, due to a deficiency of one of the coagulation factors (antihemophilic factor or Factor VIII). The patient may experience prolonged bleeding following any injury or wound, and in severe cases there is spontaneous bleeding into muscles and joints. Bleeding in hemophilia may be treated by transfusions of plasma (which contains Factor VIII). Alternatively concentrated preparations of Factor VIII, obtained by freezing fresh plasma, may be administered. Hemophilia is controlled by a sex-linked gene, which means that it is almost exclusively restricted to males: women can carry the disease and pass it on to their sons without being affected themselves.
A group of hereditary bleeding disorders marked by deficiencies of blood-clotting proteins. Hemophilias are rare. Hemophilia A affects 1 in 5,000 to 10,000 boys; hemophilia B is present in about 1 in 30,000 boys.
A sex-linked disorder in which the person’s blood does not clot properly.
A hereditary bleeding disorder arising from the insufficiency of factor VIII, one among a sequence of vital blood proteins necessary for the process of blood coagulation.
An inherited familial condition characterized by pronounced bleeding even from minor injuries due to a deficiency in the blood’s clotting ability. While it is passed down through the maternal lineage, this defect predominantly impacts male members of the family.