Intracellular aggregates of actin and actin-associated proteins, often occurring as rod shapes in the neurons of individuals affected with certain neurodegenerative disorders, such as alzheimer’s disease and creutzfeldt-jakob disease. Hirano bodies are frequently seen in hippocampal pyramidal cells. Intracellular aggregates of actin and actin-associated proteins, often occurring as rod shapes in the neurons of individuals affected with certain neurodegenerative disorders, such as alzheimer’s disease and creutzfeldt-jakob disease. Hirano bodies are frequently seen in hippocampal pyramidal cells.