Various physical substrates (surfaces) onto which have been “attached” genetic materials (DNA, RNA, oligonucleotides, etc.). Relevant complementary genetic materials (e.g., DNA, RNA, oligonucleotides, etc.) then are hybridized onto those attached-tosurface genetic materials for various specific purposes (e.g., detection of the presence of those unattached genetic materials, in the case of biosensor’s hybridization surface).
One of the technologies that can be utilized to assay (evaluate) DNA from hybridization surfaces is Matrix-Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry (MALDI-TOF-MS).