Cells artificially created by fusion of activated lymphocytes with neoplastic cells. The resulting hybrid cells are cloned and produce pure or “monoclonal” antibodies or T-cell products, identical to those produced by the immunologically competent parent, and continually grow and divide as the neoplastic parent.
The cell line produced by fusing a myeloma (tumor cell) with a lymphocyte (which makes antibodies); it continues indefinitely to express the immunoglobulins (antibodies) of both parent cells.
A hybrid cell created by fusing a B lymphocyte with a long-lived neoplastic plasma cell, or a T lymphocyte with a lymphoma cell. A B-cell hybridoma secretes a single specific antibody.
A cell produced by the fusion of a spleen cell from a mouse immunized with a specific antigen and a human multiple myeloma cell (a cancerous plasma B cell that makes antibodies). After the fusion, cells are screened to identify those capable of producing a continuous supply of monoclonal antibodies to the specific antigen.