Increased spleen function.
A condition in which too many red blood cells are destroyed by the spleen, which is often enlarged.
Condition marked by an enlarged spleen and a decrease in the number of one or more types of blood cells; it is associated with many disorders and treatment depends on the underlying cause.
Increased activity by the spleen. Hypersplenism usually results from another malady, such as liver disease (for example, cirrhosis), certain blood diseases (including leukemia and anemia), or infectious or parasitic diseases (such as tuberculosis or malaria). Symptoms include enlargement of the spleen, pain in the upper left side of the abdomen next to the stomach, and premature feelings of fullness after meals because of the spleen’s pressure on the stomach. Most people with hypersplenism require treatment for the underlying disorder. In some cases, the spleen is removed surgically.
A decrease in the numbers of red cells, white cells, and platelets in the blood resulting from destruction or pooling of these cells by an enlarged spleen. Hypersplenism may occur in any condition in which there is enlargement of the spleen.
Increased sequestration of blood cells by the spleen.
Splenomegaly is a condition characterized by the enlargement and overactivity of the spleen, which is linked to blood disorders. Among the functions of the spleen is the breakdown of aging and worn-out blood cells. However, in cases of an overactive spleen, it may start to destroy blood cells regardless of their age and condition, leading to a deficiency in various types of blood cells. In most instances, an enlarged spleen accompanies this condition.
When the condition of an overactive spleen occurs without any specific cause, it is referred to as primary hypersplenism. However, more commonly, it is a secondary condition associated with other disorders, such as Hodgkin’s disease or malaria, where the spleen becomes enlarged.
Hypersplenism is characterized by signs such as anemia and thrombocytopenia (low platelet count). It may also result in reduced resistance to infections. Primary hypersplenism is treated through splenectomy, which involves the removal of the spleen. On the other hand, treatment for secondary hypersplenism focuses on managing the underlying cause responsible for the enlarged spleen.