Drugs used in the management of type 2 diabetes mellitus. They fall into several different categories depending on their site of action. Some stimulate insulin release, some improve the responsiveness of the insulin receptors on the adipocytes and muscle, and some downregulate gluconeogenesis. Some drugs have more than one site of action. Metformin, a biguanide, (Glucophage) for example, potentiates the action of the insulin receptor thus decreasing insulin resistance. Metformin can assist in weight loss in the diabetic-obese person. Sulfonylurea (tolbutamide) stimulates insulin release, increases peripheral insulin sensitivity, and improves glucose signaling; however, unfortunately it also stimulates weight gain. Thiozolodine derivatives, that is, pioglitizone, increase insulin sensitivity, increase receptor activity, suppress gluconeogenesis, and improve glucose use. Benflourex decreases blood lipids and decreases insulin resistance.