A soluble factor produced by monocytes, macrophages, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. IL-1 consists of two distinct forms, IL-1 alpha and IL-1 beta which perform the same functions but are distinct proteins. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation. The factor is distinct from interleukin-2.
A cytokine (glycoprotein) release by activated macrophages, during the inflammatory stage of immune system response to an infection, which promotes the growth of epithelial (skin) cells and white blood cells. Recent research has indicated that too much IL- 1 is linked to the development of rheumatoid arthritis, diabetes, inflammatory bowel disease, and other autoimmune diseases.
A protein which causes high temperature.