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  • Insulin analogue

    Any synthetic insulin in which small changes in the amino acid structure of the polypeptide result in changes in the onset, peak effect, or duration of the molecule’s physiological effects. Insulin aspart, glargine, and lispro are insulin analogues.  

  • Insular

    Relating to any insula, e.g., the insular cortex of the brain.  

  • Insufflator

    A device for blowing powders or a gas into a cavity.  

  • Transtracheal insufflation

    The introduction of oxygen into the trachea during mechanical ventilation in order to decrease dead space.  

  • Venous insufficiency

    A failure of the valves of the veins to function, which interferes with venous return to the heart, and may produce edema.  

  • Velopharyngeal insufficiency

    Failure of the palatal sphincter to close, with inadequate separation of the nasopharynx from the oropharynx. This may result in snoring, nasal speech, or inhalation of food into the nasal passages.  

  • Uteroplacental insufficiency

    Inadequate blood flow through the placental intervillous spaces to enable sufficient transmission of nutrients, oxygen, and fetal wastes. It may be caused by diminished maternal cardiac output due to anemia, heart disease, regional anesthesia, or supine hypotension; vasoconstriction due to chronic or pregnancy-related hypertension or uterine overstimulation; vasospasm due to pregnancy-induced hypertension; vascular sclerosis due…

  • Respiratory insufficiency

    Inadequate oxygen intake or carbon dioxide removal associated with abnormal breathing and signs and symptoms of distress.  

  • Renal insufficiency

    A reduced capacity of the kidney to remove waste products from the blood. It is preferentially known as “chronic kidney disease.” It is defined as >30 mg of urinary albumin excretion per gram of urinary creatinine, or a glomerular filtration rate of < 60mL/min/1.73m2.  

  • Pulmonary valvular insufficiency

    An imperfect closure of the pulmonary semilunar valve at the junction of the right ventricle and the pulmonary artery. The clinical consequences may include right ventricular failure.  

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