Replacing a diseased, nonfunctioning pancreas with a healthy pancreas from a donor. The pancreas, located in the upper abdomen near the stomach, produces insulin to regulate sugar levels in the blood. In people with type i diabetes, the insulin-producing cells of the pancreas no longer function. Most recipients of pancreas transplants are people with type i diabetes who have kidney disease requiring a kidney transplant or who have severe, frequent hypoglycemia (low blood sugar) that is disabling. For other people with type 1 diabetes and for people with type 2 diabetes, pancreas transplants are experimental because of the serious side effects of the immune- suppressing medications that must be taken for life to prevent organ rejection.