Palmarplantar hyperorthokeratosis with precocious periodontal destruction in the primary and permanent dentition. Thought to be the result of homozygosity of autosomal recessive genes.
Papillon–Lefevre syndrome is an uncommon genetic condition that impacts the skin and gums. It leads to regions of dense, fissured skin. Furthermore, from an early age, the gums become susceptible to infections. Severe gum conditions result in the early loss of milk teeth, and by the age of 20, it might lead to the loss of all adult teeth.