A rare condition caused by lymph node abnormalities, skin rashes, and abnormally circulating T cells. Sezary syndrome is a form of the primary cutaneous T-cell lymphoma (cancer of the lymph nodes). In this syndrome, there is an abnormal overgrowth of lymphoid cells (lymphocytes) in the skin, liver, spleen, and lymph nodes. Immunosuppression may result in an increased incidence of squamous cell carcinoma (a form of SKIN cancer) and internal malignant neoplasms (cancerous tvunors). The first signs of Sezary syndrome are often red, scaly patches on the skin that spread to form a severe, flaky, itchy rash over the entire body. Other symptoms include an accumulation of fluid beneath the skin, baldness, and distorted nail growth. Treatment is with anticancer drugs and radiation therapy. However, Sezary syndrome is an aggressive disease with a median survival rate of less than 3 years.
An advanced stage of cutaneous T-cell lymphoma in which there is widespread involvement of the skin and systemic circulation of malignant cells.
A leukemic phase of CTCL that develops in some patients, characterized by the appearance of malignant T cells in the peripheral blood and sometimes in the lymph nodes. The syndrome is named for Alfred Sezary (1880-1956), a French dermatologist.
An uncommon disorder characterized by an excessive proliferation of lymphocytes (a type of white blood cell involved in the immune system) in the skin, liver, spleen, and lymph nodes. This condition primarily impacts individuals in their middle to later years of life. Its initial indication is the emergence of red, scaly patches on the skin, which later extend and create an itchy, peeling rash. Additionally, fluid buildup beneath the skin, hair loss, and abnormal nail growth might occur.
Sézary syndrome can be linked to leukemia at times. The treatment involves the use of anticancer medications and radiotherapy.