A potent antimicrobial agent (steroid, antibiotic) that was discovered in the tissues of the dogfish shark in 1992. It has been found to be active against a broad spectrum of bacteria, protozoa, and fungi. Squalamine was chemically synthesized by man in 1993.
An antiangiogenic protein, originally isolated from dog sharks. It has been used to treat the neovascularization of age-related macular degeneration and to limit blood vessel proliferation needed by a cancer for it to spread and survive.