WAGR syndrome is a constellation of abnormalities that include Wilm’s tumor, aniridia, genitourinary anomalies or gonadoblastoma, and mental retardation (WAGR). Wilms tumor is the most common form of childhood cancer and involves the kidneys (also known as nephroblastoma). Aniridia is the absence of the colored portion of the eye (the iris). Gonadoblastoma are cancer cells that form the testes in males and the ovaries in females. In order for a person to be diagnosed with WAGR syndrome, at least two of the conditions must be present, and in all but one case of WAGR syndrome, aniridia has been present. Therefore, the clinical representation will vary depending on the conditions present in the individual.