Whipple’s disease

A disease in which someone has difficulty in absorbing nutrients and passes fat in the faeces, the joints are inflamed and the lymph glands enlarged [Described 1907. After George Hoyt Whipple (1878-1976), US pathologist. Nobel prize for Pathology and Medicine 1934.]


A rare disease, occurring only in males, in which absorption of digested food in the intestine is reduced. As well as symptoms and signs of malabsorption there is usually skin pigmentation and arthritis. Diagnosis is made by jejunal biopsy; microorganisms have been found in the mucosa, and the disease usually responds to prolonged antibiotic treatment.


An infectious disease with gastrointestinal and systemic features caused by the organism Trophermya whippeli. This rare disease resembles idiopathic steatorrhea.


A condition characterized by the diminished ability of the small intestine to absorb nutrients properly. Symptoms of this disorder encompass diarrhea, abdominal pain, gradual weight loss, joint pain, enlarged lymph nodes, atypical skin pigmentation, anemia, and fever. While the exact cause remains unidentified, it is suspected to be associated with an unknown bacterial infection.


This is a rare disorder, also known as intestinal lipodystrophy, which can impact multiple organs in the body. Its symptoms encompass steatorrhea (the presence of fat in feces due to poor absorption), abdominal pain, joint discomfort, swollen lymph nodes, gradual weight loss, anemia, and fever. Additionally, it can affect the heart, lungs, and brain. This condition is most frequently observed in middle-aged men.


The suspected cause of this condition is bacterial in nature, with affected tissues discovered to contain macrophages (a type of scavenging cell) that harbor rod-shaped bacteria.


The treatment involves administering antibiotic drugs for a minimum of one year. Additionally, dietary supplements are utilized to address nutritional deficiencies that arise due to malabsorption.


 


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