Wolf-Hirschhorn syndrome is an extremely rare chromosomal disorder. It affects Chromosome 4, usually in the form of a partial deletion (absence of part of the short arm of Chromosome 4). The deletion of chromosomal material results in certain facial dysmorphic features and neurological manifestations. However, the amount of chromosomal material deleted varies from individual to individual. Large deletions are associated with more severe symptoms. Wolf- Hirschhorn syndrome is not usually inherited unless a parent is a translocation carrier (i.e., part of Chromosome 4 has been transferred to a different position). Cases of Wolf-Hirschhorn syndrome are more often a sporadic event. Wolf-Hirschhorn syndrome may also be known as Wolf syndrome; Wolf-Hirschhorn chromosome region (WHCR); partial deletion of the short arm of Chromosome 4; Chromo¬ some 4, partial monosomy 4p; and 4p syndrome, partial.