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Drugs that help lower blood pressure. Blood pressure measures the force with which blood moves through the blood vessels. While blood pressure normally varies throughout the day, rising during exercise and falling during sleep, in some people the blood pressure stays high all the time. Some cases of high blood pressure (hypertension) can be treated with lifestyle changes — losing weight, lowering salt intake, exercising more, stopping smoking — but in most cases, hypertension is treated with medication to help control the condition. There are five classes of medication used to treat hypertension.