1.0Glossaryhttps://www.healthbenefitstimes.com/glossaryGlossaryhttps://www.healthbenefitstimes.com/glossary/author/adminglossary/rich600338<blockquote class="wp-embedded-content" data-secret="WSVzhGX4om"><a href="https://www.healthbenefitstimes.com/glossary/castleman-disease/">Castleman disease</a></blockquote><iframe sandbox="allow-scripts" security="restricted" src="https://www.healthbenefitstimes.com/glossary/castleman-disease/embed/#?secret=WSVzhGX4om" width="600" height="338" title="“Castleman disease” — Glossary" data-secret="WSVzhGX4om" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" class="wp-embedded-content"></iframe><script> /*! This file is auto-generated */ !function(d,l){"use strict";l.querySelector&&d.addEventListener&&"undefined"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!/[^a-zA-Z0-9]/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret="'+t.secret+'"]'),o=l.querySelectorAll('blockquote[data-secret="'+t.secret+'"]'),c=new RegExp("^https?:$","i"),i=0;i<o.length;i++)o[i].style.display="none";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute("style"),"height"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):"link"===t.message&&(r=new URL(s.getAttribute("src")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener("message",d.wp.receiveEmbedMessage,!1),l.addEventListener("DOMContentLoaded",function(){for(var e,t,s=l.querySelectorAll("iframe.wp-embedded-content"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute("data-secret"))||(t=Math.random().toString(36).substring(2,12),e.src+="#?secret="+t,e.setAttribute("data-secret",t)),e.contentWindow.postMessage({message:"ready",secret:t},"*")},!1)))}(window,document); //# sourceURL=https://www.healthbenefitstimes.com/glossary/wp-includes/js/wp-embed.min.js </script> Castleman disease (CD), also referred to as angiofollicular lymph node hyperplasia, is a heterogeneous group of lymphoproliferative disorders, characterized by abnormal growth of the lymph nodes. There are three histopathological variants of CD: hyaline-vascular type, which accounts for approximately 80-90% of reported cases; plasma cell type; and an intermediate, or mixed, histological type. Clinical presentation of CD appears to be either localized or generalized (multicentric); however, there is controversy about whether the multicentric form is a distinct entity or simply a form of the plasma cell type (National Organization for Rare Disorders, Inc. [NORD], 2000). There is also some evidence that CD constitutes a spectrum of benign to malignant diseases and that if left untreated, the benign form of the disease may serve as a precursor to the malignant form (Parez et al.).An occasionally aggressive illness marked by excessive growth of lymphoid tissue either localized in a single lymph node group or in multiple regions of the body. Although the cause is not precisely known, its associations with acquired immunodeficiency syndrome, Kaposi’s sarcoma, and human herpes virus 8 infection have led some experts to propose that it has an infectious basis. Localized disease responds well to surgical resection. Widespread disease can sometimes be treated effectively with chemotherapy.