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</html><description>Hydrolethalus syndrome is a recessively inherited lethal malformation syndrome involving the central nervous system. Prenatal diagnosis is most common, and the fetuses commonly present with hydrocephaly (with significant functional deficits), micrognathia (underdevelopment of the jaw), polydactyly (more than the normal number of fingers and toes), and a key-shaped defect of the occipital bone.</description></oembed>
