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The nitrogen analogues of mustard gas are among the most important ALKYLATING AGENTS used in the treatment of various forms of malignant disease. They include chlormethine, busulphan, chlorambucil and melphalan.Any of the alkylating drugs used to treat several solid and hematological malignancies such as Hodgkin’s disease, multiple myeloma, and some leukemias. Nitrogen mustards include mechlorethamine, cyclophosphamide, uracil mustard, melphalan, and chlorambucil.