1.0Glossaryhttps://www.healthbenefitstimes.com/glossaryGlossaryhttps://www.healthbenefitstimes.com/glossary/author/adminglossary/rich600338<blockquote class="wp-embedded-content" data-secret="kj3wXdo2l9"><a href="https://www.healthbenefitstimes.com/glossary/osteocalcin/">Osteocalcin</a></blockquote><iframe sandbox="allow-scripts" security="restricted" src="https://www.healthbenefitstimes.com/glossary/osteocalcin/embed/#?secret=kj3wXdo2l9" width="600" height="338" title="“Osteocalcin” — Glossary" data-secret="kj3wXdo2l9" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" class="wp-embedded-content"></iframe><script> /*! This file is auto-generated */ !function(d,l){"use strict";l.querySelector&&d.addEventListener&&"undefined"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!/[^a-zA-Z0-9]/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret="'+t.secret+'"]'),o=l.querySelectorAll('blockquote[data-secret="'+t.secret+'"]'),c=new RegExp("^https?:$","i"),i=0;i<o.length;i++)o[i].style.display="none";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute("style"),"height"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):"link"===t.message&&(r=new URL(s.getAttribute("src")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener("message",d.wp.receiveEmbedMessage,!1),l.addEventListener("DOMContentLoaded",function(){for(var e,t,s=l.querySelectorAll("iframe.wp-embedded-content"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute("data-secret"))||(t=Math.random().toString(36).substring(2,12),e.src+="#?secret="+t,e.setAttribute("data-secret",t)),e.contentWindow.postMessage({message:"ready",secret:t},"*")},!1)))}(window,document); //# sourceURL=https://www.healthbenefitstimes.com/glossary/wp-includes/js/wp-embed.min.js </script> A bone‐specific protein produced by the osteoblast which may play a role in osteoclast recruitment, found in the extracellular matrix of bone, dentin, and the serum of circulating blood. A marker for bone remodeling or mineralization. This vitamin K‐dependent, calcium‐binding protein is produced by osteoblasts and is the most abundant noncollagen protein in bone. Because of calcium‐binding sites, it plays a role in bone matrix mineralization or in regulation of crystal growth. In addition, its increased serum concentration is a marker of increased bone turnover in disease states (e.g., Paget’s disease or postmenopausal osteoporosis). It has a low molecular weight and contains three alpha‐carboxyglutamic acid residues per molecule. Called also gammalinolenic acid (GLA) protein.A noncollagenous protein found in bone and dentin, also refer to as bone gammacarboxyglutamic acid-containing protein.A calcium-binding protein in bone, essential for the normal mineralisation of bone. Its synthesis requires vitamin K, and is controlled by vitamin D.A protein whose synthesis is dependent on vitamin K and which acts to promote mineral deposition in bone. This protein contains numerous glutamic acid residues, which are carboxylated post-translationally through the action of the vitamin K-dependent epoxide cycle.