1.0Glossaryhttps://www.healthbenefitstimes.com/glossaryGlossaryhttps://www.healthbenefitstimes.com/glossary/author/adminglossary/rich600338<blockquote class="wp-embedded-content" data-secret="zYF0uW4FA2"><a href="https://www.healthbenefitstimes.com/glossary/pagets-disease/">Paget’s disease</a></blockquote><iframe sandbox="allow-scripts" security="restricted" src="https://www.healthbenefitstimes.com/glossary/pagets-disease/embed/#?secret=zYF0uW4FA2" width="600" height="338" title="“Paget’s disease” — Glossary" data-secret="zYF0uW4FA2" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" class="wp-embedded-content"></iframe><script> /*! This file is auto-generated */ !function(d,l){"use strict";l.querySelector&&d.addEventListener&&"undefined"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!/[^a-zA-Z0-9]/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret="'+t.secret+'"]'),o=l.querySelectorAll('blockquote[data-secret="'+t.secret+'"]'),c=new RegExp("^https?:$","i"),i=0;i<o.length;i++)o[i].style.display="none";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute("style"),"height"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):"link"===t.message&&(r=new URL(s.getAttribute("src")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener("message",d.wp.receiveEmbedMessage,!1),l.addEventListener("DOMContentLoaded",function(){for(var e,t,s=l.querySelectorAll("iframe.wp-embedded-content"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute("data-secret"))||(t=Math.random().toString(36).substring(2,12),e.src+="#?secret="+t,e.setAttribute("data-secret",t)),e.contentWindow.postMessage({message:"ready",secret:t},"*")},!1)))}(window,document); //# sourceURL=https://www.healthbenefitstimes.com/glossary/wp-includes/js/wp-embed.min.js </script> Osteitis deformans. Disease of unknown etiology, characterized by enlargement of the cranial bones and often the maxilla and mandible. Cotton‐wool appearance of bone on a radiograph may be a diagnostic feature.An inflammatory cancerous condition of the areola and nipple, usually associated with carcinoma or the milk ducts and other tissues of the breast.A form of breast cancer which starts as an itchy rash round the nipple [Described 1877. After Sir James Paget (1814-99), British surgeon.]A bone disorder involving disruption of the normal processes that break down old and rebuild new bone tissue; as a result, bones weaken, thicken, become deformed, and fracture easily. Paget’s disease generally affects people of middle or old age and men more often than women; its causes are unknown, though some suggest an infection, possibly from a virus. The disease sometimes runs in families, but evidence is unclear as to whether it is a genetic disorder.Disease of bone, common in the middle aged and elderly, in which there is excessive bone destruction and disorganized bone structure, sometimes leading to bone pain, frequent fractures, and skeletal deformities.A disorder characterized by increased bone resorption and formation, causing thickening and softening of bones.An irregular thickening and softening of the bones of unknown cause. It is most common in adults older than 50. The bones most often affected by Paget disease are the hip bones, shin bones, thighbone, skull, spine, and collarbone. The disease makes these bones enlarged, deformed, and easily fractured. Bone pain is the most common symptom. The chronic aching sensation tends to worsen at night. The affected areas may feel warm and tender. When Paget disease affects the skull bones, it may cause deafness. Increased blood flow through the diseased bones may strain the heart, which can cause heart failure. Rarely, a bone tumor may develop.