1.0Glossaryhttps://www.healthbenefitstimes.com/glossaryGlossaryhttps://www.healthbenefitstimes.com/glossary/author/adminglossary/rich600338<blockquote class="wp-embedded-content" data-secret="P61Lqh9NDa"><a href="https://www.healthbenefitstimes.com/glossary/platelet-derived-growth-factor-pdgf/">Platelet-derived growth factor (PDGF)</a></blockquote><iframe sandbox="allow-scripts" security="restricted" src="https://www.healthbenefitstimes.com/glossary/platelet-derived-growth-factor-pdgf/embed/#?secret=P61Lqh9NDa" width="600" height="338" title="“Platelet-derived growth factor (PDGF)” — Glossary" data-secret="P61Lqh9NDa" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" class="wp-embedded-content"></iframe><script> /*! This file is auto-generated */ !function(d,l){"use strict";l.querySelector&&d.addEventListener&&"undefined"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!/[^a-zA-Z0-9]/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret="'+t.secret+'"]'),o=l.querySelectorAll('blockquote[data-secret="'+t.secret+'"]'),c=new RegExp("^https?:$","i"),i=0;i<o.length;i++)o[i].style.display="none";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute("style"),"height"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):"link"===t.message&&(r=new URL(s.getAttribute("src")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener("message",d.wp.receiveEmbedMessage,!1),l.addEventListener("DOMContentLoaded",function(){for(var e,t,s=l.querySelectorAll("iframe.wp-embedded-content"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute("data-secret"))||(t=Math.random().toString(36).substring(2,12),e.src+="#?secret="+t,e.setAttribute("data-secret",t)),e.contentWindow.postMessage({message:"ready",secret:t},"*")},!1)))}(window,document); //# sourceURL=https://www.healthbenefitstimes.com/glossary/wp-includes/js/wp-embed.min.js </script> An angiogenic growth factor produced by the blood's platelet cells which attracts the growth of capillaries into the vicinity of a fresh wound. This action releases still other growth factors, and starts the process of building a fibrin network, to support the subsequent (blood) clot. PDGF is a competence factor (i.e., a growth factor that is required to make a cell able or competent to react to other growth factors). PDGF is normally contained within the platelet cells, so does not circulate in the blood in a form enabling it to be freely available to its "target cells." This "containment" of PDGF in platelets ensures site-specific delivery of the PDGF directly to a wound site, so stimulus (i.e., of capillary growth) is localized to the actual wound site. After PDGF has caused the formation of the initial clot at a wound site, PDGF attracts connective tissue cells into the vicinity of the wound (to start the tissue-repair process). PDGF also acts as a mitogen (substance causing cell to divide and thus multiply) for connective tissue cells, granulocytes, and monocytes (each of which is involved in the wound's healing process).A polypeptide that stimulates collagen synthesis, smooth muscle formation, tissue repair, and the proliferation of fibroblasts and microglia.