{"version":"1.0","provider_name":"Glossary","provider_url":"https:\/\/www.healthbenefitstimes.com\/glossary","author_name":"Glossary","author_url":"https:\/\/www.healthbenefitstimes.com\/glossary\/author\/adminglossary\/","title":"Angiotensin-converting enzyme inhibitors - Definition of Angiotensin-converting enzyme inhibitors","type":"rich","width":600,"height":338,"html":"<blockquote class=\"wp-embedded-content\" data-secret=\"VBb128XQuW\"><a href=\"https:\/\/www.healthbenefitstimes.com\/glossary\/angiotensin-converting-enzyme-inhibitors\/\">Angiotensin-converting enzyme inhibitors<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/www.healthbenefitstimes.com\/glossary\/angiotensin-converting-enzyme-inhibitors\/embed\/#?secret=VBb128XQuW\" width=\"600\" height=\"338\" title=\"&#8220;Angiotensin-converting enzyme inhibitors&#8221; &#8212; Glossary\" data-secret=\"VBb128XQuW\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script>\n\/*! This file is auto-generated *\/\n!function(d,l){\"use strict\";l.querySelector&&d.addEventListener&&\"undefined\"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!\/[^a-zA-Z0-9]\/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret=\"'+t.secret+'\"]'),o=l.querySelectorAll('blockquote[data-secret=\"'+t.secret+'\"]'),c=new RegExp(\"^https?:$\",\"i\"),i=0;i<o.length;i++)o[i].style.display=\"none\";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute(\"style\"),\"height\"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):\"link\"===t.message&&(r=new URL(s.getAttribute(\"src\")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener(\"message\",d.wp.receiveEmbedMessage,!1),l.addEventListener(\"DOMContentLoaded\",function(){for(var e,t,s=l.querySelectorAll(\"iframe.wp-embedded-content\"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute(\"data-secret\"))||(t=Math.random().toString(36).substring(2,12),e.src+=\"#?secret=\"+t,e.setAttribute(\"data-secret\",t)),e.contentWindow.postMessage({message:\"ready\",secret:t},\"*\")},!1)))}(window,document);\n\/\/# sourceURL=https:\/\/www.healthbenefitstimes.com\/glossary\/wp-includes\/js\/wp-embed.min.js\n<\/script>\n","description":"Agents that inhibit angiotensin-converting enzyme (a potent vasoconstrictor) and promote relaxation of blood vessels.A drug which inhibits the conversion of angiotensin I to II, which constricts arteries, used in the treatment of hypertension and heart failure.The enzyme that converts angiotensin I to angiotensin II is called angiotensin-converting enzyme. Angiotensin II controls the blood pressure while angiotensin | has no such activity. Inhibition of the enzyme that converts angiotensin I to angiotensin II should therefore lower the blood pressure, and ACE inhibitors have a valuable role in treating heart failure when thiazides and betablockers cannot be used or fail to work, especially after myocardial infarction. Captopril was the first ACE inhibitor to be synthesised: it reduces peripheral resistance by causing arteriolar dilatation and thus lowers blood pressure. Other drugs such as enalapril, lisinopril, cilazapril, quinapril and ramipril have since been developed. Some kidney disorders increase the production of angiotensin II and so cause hypertension.Any of the therapeutic agents that inhibit conversion of angiotensin I to angiotensin II. ACE inhibitors are used to treat hypertension and heart failure and to protect kidney function in patients with diabetes mellitus."}