{"version":"1.0","provider_name":"Glossary","provider_url":"https:\/\/www.healthbenefitstimes.com\/glossary","author_name":"Glossary","author_url":"https:\/\/www.healthbenefitstimes.com\/glossary\/author\/adminglossary\/","title":"Cushing\u2019s syndrome - Definition of Cushing\u2019s syndrome","type":"rich","width":600,"height":338,"html":"<blockquote class=\"wp-embedded-content\" data-secret=\"jHillTotiv\"><a href=\"https:\/\/www.healthbenefitstimes.com\/glossary\/cushings-syndrome\/\">Cushing\u2019s syndrome<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/www.healthbenefitstimes.com\/glossary\/cushings-syndrome\/embed\/#?secret=jHillTotiv\" width=\"600\" height=\"338\" title=\"&#8220;Cushing\u2019s syndrome&#8221; &#8212; Glossary\" data-secret=\"jHillTotiv\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script>\n\/*! This file is auto-generated *\/\n!function(d,l){\"use strict\";l.querySelector&&d.addEventListener&&\"undefined\"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!\/[^a-zA-Z0-9]\/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret=\"'+t.secret+'\"]'),o=l.querySelectorAll('blockquote[data-secret=\"'+t.secret+'\"]'),c=new RegExp(\"^https?:$\",\"i\"),i=0;i<o.length;i++)o[i].style.display=\"none\";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute(\"style\"),\"height\"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):\"link\"===t.message&&(r=new URL(s.getAttribute(\"src\")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener(\"message\",d.wp.receiveEmbedMessage,!1),l.addEventListener(\"DOMContentLoaded\",function(){for(var e,t,s=l.querySelectorAll(\"iframe.wp-embedded-content\"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute(\"data-secret\"))||(t=Math.random().toString(36).substring(2,12),e.src+=\"#?secret=\"+t,e.setAttribute(\"data-secret\",t)),e.contentWindow.postMessage({message:\"ready\",secret:t},\"*\")},!1)))}(window,document);\n\/\/# sourceURL=https:\/\/www.healthbenefitstimes.com\/glossary\/wp-includes\/js\/wp-embed.min.js\n<\/script>\n","description":"A condition caused by either excessive amounts of an adrenal hormone (cortisol) in the blood or excessive administration of a synthetic hormone (corticosteroid), which results in an altered body appearance and often hypertension.An endocrine disorder usually affecting young women, produced by over-secretion of cortisone and marked by mood swings, irritability, agitation, physical disfigurement, obesity, muscular atrophy and fatigue.A disease due to overproduction of glucocorticoids by the adrenal cortex. The syndrome is characterized by abnormal glucose tolerance, excess muscle protein degradation, fatigue, osteoporosis, excess hair growth, excess fat deposition on shoulders and abdomen, and skin discoloration.Cushing\u2019s syndrome, or hypercortisolism, is a hormonal disorder that is caused by an excess of the hormone cortisol. The syndrome is relatively rare, and its etiology has been traced to an abnormal functioning of the pituitary gland. Other causes may be as the result of high doses of cortisol or other glucocorticoid (steroid) hormones taken for pro\u00ac longed periods of time for the treatment of asthma, rheumatoid arthritis, lupus, or certain allergies (Shin, 1999). The syndrome is distinguishable from Cushing\u2019s disease in that the latter involves tumors in the pituitary that cause the excessive amounts of cortisol.Disorder caused by excessive cortisol; symptoms include a moon face, mental or emotional disturbances, high blood pressure, weight gain, and, in women, abnormal growth of facial and body hair. The syndrome may be due to overproduction of cortisol by the adrenal glands or by prolonged administration of certain drugs.A metabolic disorder resulting from the chronic and excessive production of cortisol by the adrenal cortex.Condition caused by excessive cortisol and other adrenal hormones. Symptoms include a distinctive type of obesity, high blood pressure, muscle wasting and weakness, fragile skin, brittle bones, glucose intolerance, and emotional disorders.The ailment in question arises from an anomalous surplus of corticosteroid hormones, secreted by the adrenal glands. These hormones assume command over the body's regulation of nutrient utilization and the elimination of salts and water through urine. Manifestations of this condition encompass elevated glucose levels, a facial countenance reminiscent of the moon, an escalation in body mass, and augmented blood pressure.Cushing's syndrome is a hormonal disorder characterized by an excessive level of corticosteroid hormones circulating in the bloodstream. This condition manifests with distinct physical features, including a reddened, moon-shaped face, wasting of the limbs, thickening of the trunk, and a humped upper back. Additional symptoms consist of acne, stretch marks on the skin, bruising, osteoporosis leading to reduced bone density, heightened vulnerability to infections and peptic ulcers, and, in women, increased hairiness. Mental changes are common, ranging from depression, insomnia, paranoia to euphoria. Edema, hypertension, and diabetes mellitus may also develop as associated complications. In children, Cushing's syndrome can inhibit normal growth patterns. Prompt diagnosis and appropriate management are crucial in addressing the diverse manifestations of this condition.The primary cause of hormonal excess in Cushing's syndrome is typically attributed to prolonged administration of corticosteroid medications. In such cases, the syndrome tends to manifest in milder forms. However, in other instances, elevated hormone levels result from either excessive activity of the adrenal glands caused by an adrenal tumor or an abnormal growth in the pituitary gland affecting the production of ACTH (adrenocorticotrophic hormone). ACTH stimulates the adrenal glands, leading to increased hormone secretion. Understanding the underlying cause is essential for accurate diagnosis and appropriate management of Cushing's syndrome.In cases of Cushing's syndrome caused by corticosteroid drugs, the syndrome typically resolves when the dosage of the medication is gradually reduced. Conversely, if the syndrome is a result of an adrenal gland tumor, surgical removal of the tumor is often recommended. When a pituitary tumor is identified as the underlying cause, it can be addressed through surgical removal or treated with a combination of radiation therapy and drug therapy to reduce its size. Following surgical intervention in either scenario, hormone replacement therapy becomes necessary to restore hormonal balance and ensure proper bodily functions. The specific approach to treatment depends on the individual case, and healthcare professionals will determine the most suitable course of action for each patient."}