{"version":"1.0","provider_name":"Glossary","provider_url":"https:\/\/www.healthbenefitstimes.com\/glossary","author_name":"Glossary","author_url":"https:\/\/www.healthbenefitstimes.com\/glossary\/author\/adminglossary\/","title":"Pemphigus - Definition of Pemphigus","type":"rich","width":600,"height":338,"html":"<blockquote class=\"wp-embedded-content\" data-secret=\"5UMOr3zmTq\"><a href=\"https:\/\/www.healthbenefitstimes.com\/glossary\/pemphigus\/\">Pemphigus<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/www.healthbenefitstimes.com\/glossary\/pemphigus\/embed\/#?secret=5UMOr3zmTq\" width=\"600\" height=\"338\" title=\"&#8220;Pemphigus&#8221; &#8212; Glossary\" data-secret=\"5UMOr3zmTq\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script>\n\/*! This file is auto-generated *\/\n!function(d,l){\"use strict\";l.querySelector&&d.addEventListener&&\"undefined\"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!\/[^a-zA-Z0-9]\/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret=\"'+t.secret+'\"]'),o=l.querySelectorAll('blockquote[data-secret=\"'+t.secret+'\"]'),c=new RegExp(\"^https?:$\",\"i\"),i=0;i<o.length;i++)o[i].style.display=\"none\";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute(\"style\"),\"height\"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):\"link\"===t.message&&(r=new URL(s.getAttribute(\"src\")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener(\"message\",d.wp.receiveEmbedMessage,!1),l.addEventListener(\"DOMContentLoaded\",function(){for(var e,t,s=l.querySelectorAll(\"iframe.wp-embedded-content\"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute(\"data-secret\"))||(t=Math.random().toString(36).substring(2,12),e.src+=\"#?secret=\"+t,e.setAttribute(\"data-secret\",t)),e.contentWindow.postMessage({message:\"ready\",secret:t},\"*\")},!1)))}(window,document);\n\/\/# sourceURL=https:\/\/www.healthbenefitstimes.com\/glossary\/wp-includes\/js\/wp-embed.min.js\n<\/script>\n","thumbnail_url":"https:\/\/www.healthbenefitstimes.com\/glossary\/wp-content\/uploads\/2020\/02\/Pemphigus.jpg","thumbnail_width":350,"thumbnail_height":231,"description":"Refers to a group of autoimmune bullous diseases (pemphigus vulgaris, pemphigus vegetans, pemphigus erythematosus) that affects skin and mucous membranes primarily between the fourth and sixth decades of life.A generalized, sometimes fatal, skin disease characterized by recurring crops of large blisters.A rare disease where large blisters form inside the skin.Disease of the skin, characterized by thin-walled bullae (blisters) arising from normal skin or mucous membrane; the bullae frequently rupture, leaving raw patches that often become infected. Treatment is by corticosteroids.Any of several distinctive skin diseases marked by successive outbreaks of blisters. There are several types; for example, benign familial pemphigus, which is a hereditary condition; and pemphigus vulgaris, a rare serious disease occurring in middle age and initially affecting the mucous membranes.Autoimmune disease of the skin in which the cells of the epidermis lose their adhesion to each other, resulting in blister formation.An acute or chronic autoimmune disease principally of adults but sometimes found in children, characterized by occurrence of successive crops of bullae that appear suddenly on apparently normal skin and disappear, leaving pigmented spots. Antibodies form against cellular adhesion molecules in the epidermis, causing layers of the skin to separate (and blister). A characteristic sign is a positive Nikolsky\u2019s sign: when pressure is applied to an area as if trying to push the skin parallel to the surface, the skin will detach from the lower layers.An autoimmune condition characterized by the immune system generating antibodies against particular proteins found in the skin and mucous membrane. The presence of these antibodies triggers a response that results in the detachment of skin cells.Pemphigus is an infrequent yet severe skin disorder characterized by the emergence of numerous blisters on both the skin and within the oral cavity. Typically afflicting individuals aged 40 to 60, this condition initiates with blister formation in the mouth, subsequently extending to the skin. These blisters rupture, resulting in raw areas that may become infected and eventually develop into crusts. Even seemingly unaffected skin might blister upon gentle pressure. If the disease extensively affects a substantial body area, there can be substantial skin loss, potentially leading to bacterial infection and, in certain cases, fatality.Confirmation of the diagnosis involves a skin biopsy. Pemphigus is typically managed through an extended regimen of corticosteroid medications and, in specific instances, immunosuppressants. Antibiotics might also be prescribed.A skin condition, either acute or chronic, marked by irregularly spaced blisters that emerge on healthy or mildly inflamed skin. It can sometimes be accompanied by intense overall health symptoms."}