Peroxisomal oxidation in the kidney and liver is an important aspect of drug metabolism. The peroxisomes are a class of subcellular organelles that are important in protection against oxygen toxicity. They have a high level of catalase activity. The peroxisomal fatty acid oxidation pathway differs in three important ways from the mitochondrial pathway. First, the initial dehydrogenation is accomplished by a cyanide-insensitive oxidase that produces H2O2. This H2O2 is rapidly extinguished by catalase. Second, the enzymes of the pathway prefer long-chain fatty acids and are slightly different in structure from those (with the same function) of the mitochondrial pathway. Third, (i-oxidation in the peroxisomes stops at eight carbons rather than proceeding all the way to acetyl CoA. The peroxisomes also serve in the conversion of cholesterol to bile acids and in the formation of ether lipids (plasmalogens).<\/p>\n
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Peroxisomal oxidation in the kidney and liver is an important aspect of drug metabolism. The peroxisomes are a class of subcellular organelles that are important in protection against oxygen toxicity. They have a high level of catalase activity. The peroxisomal fatty acid oxidation pathway differs in three important ways from the mitochondrial pathway. First, the […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-107099","post","type-post","status-publish","format-standard","hentry","category-p"],"yoast_head":"\n