{"id":107564,"date":"2021-05-21T07:53:38","date_gmt":"2021-05-21T07:53:38","guid":{"rendered":"https:\/\/www.healthbenefitstimes.com\/glossary\/?p=107564"},"modified":"2023-08-31T06:18:15","modified_gmt":"2023-08-31T06:18:15","slug":"tangier-disease","status":"publish","type":"post","link":"https:\/\/www.healthbenefitstimes.com\/glossary\/tangier-disease\/","title":{"rendered":"Tangier disease"},"content":{"rendered":"<p>Familial HDL deficiency. A genetic disease due to a mutation in the gene for the HDL protein. Characterized by very low plasma HDL and cholesterol levels, an accumulation of cholesterol esters in the tissues, and a peculiar yellow orange color to the tonsils.<\/p>\n<hr \/>\n<p>Tangier disease is an extremely rare autosomal recessive metabolic disorder. The disease is characterized by decreased levels or even a complete absence of high-density lipoproteins (HDL) concentrations in one\u2019s plasma and increased cholesteryl esters in the tonsils, spleen, liver, skin, and lymph nodes.<\/p>\n<hr \/>\n<div class=\"group w-full text-token-text-primary border-b border-black\/10 dark:border-gray-900\/50 bg-gray-50 dark:bg-[#444654]\" data-testid=\"conversation-turn-97\">\n<div class=\"p-4 justify-center text-base md:gap-6 md:py-6 lg:px-0 m-auto\">\n<div class=\"flex flex-1 gap-4 text-base mx-auto md:gap-6 md:max-w-2xl lg:max-w-[38rem] xl:max-w-3xl }\">\n<div class=\"relative flex w-[calc(100%-50px)] flex-col gap-1 md:gap-3 lg:w-[calc(100%-115px)]\">\n<div class=\"flex flex-grow flex-col gap-3 max-w-full\">\n<div class=\"min-h-[20px] flex flex-col items-start gap-3 overflow-x-auto whitespace-pre-wrap break-words\">\n<div class=\"markdown prose w-full break-words dark:prose-invert light\">\n<p>An uncommon disorder inherited through an autosomal recessive gene, leading to cholesterol accumulation in multiple organs such as the tonsils, liver, and spleen.<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Familial HDL deficiency. A genetic disease due to a mutation in the gene for the HDL protein. Characterized by very low plasma HDL and cholesterol levels, an accumulation of cholesterol esters in the tissues, and a peculiar yellow orange color to the tonsils. Tangier disease is an extremely rare autosomal recessive metabolic disorder. The disease [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-107564","post","type-post","status-publish","format-standard","hentry","category-t"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Tangier disease - Definition of Tangier disease<\/title>\n<meta name=\"description\" content=\"Familial HDL deficiency. A genetic disease due to a mutation in the gene for the HDL protein. Characterized by very low plasma HDL and cholesterol levels, an accumulation of cholesterol esters in the tissues, and a peculiar yellow orange color to the tonsils.Tangier disease is an extremely rare autosomal recessive metabolic disorder. The disease is characterized by decreased levels or even a complete absence of high-density lipoproteins (HDL) concentrations in one\u2019s plasma and increased cholesteryl esters in the tonsils, spleen, liver, skin, and lymph nodes.An uncommon disorder inherited through an autosomal recessive gene, leading to cholesterol accumulation in multiple organs such as the tonsils, liver, and spleen.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.healthbenefitstimes.com\/glossary\/tangier-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tangier disease - Definition of Tangier disease\" \/>\n<meta property=\"og:description\" content=\"Familial HDL deficiency. A genetic disease due to a mutation in the gene for the HDL protein. Characterized by very low plasma HDL and cholesterol levels, an accumulation of cholesterol esters in the tissues, and a peculiar yellow orange color to the tonsils.Tangier disease is an extremely rare autosomal recessive metabolic disorder. The disease is characterized by decreased levels or even a complete absence of high-density lipoproteins (HDL) concentrations in one\u2019s plasma and increased cholesteryl esters in the tonsils, spleen, liver, skin, and lymph nodes.An uncommon disorder inherited through an autosomal recessive gene, leading to cholesterol accumulation in multiple organs such as the tonsils, liver, and spleen.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.healthbenefitstimes.com\/glossary\/tangier-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"Glossary\" \/>\n<meta property=\"article:published_time\" content=\"2021-05-21T07:53:38+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-08-31T06:18:15+00:00\" \/>\n<meta name=\"author\" content=\"Glossary\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Glossary\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/tangier-disease\/\",\"url\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/tangier-disease\/\",\"name\":\"Tangier disease - Definition of Tangier disease\",\"isPartOf\":{\"@id\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/#website\"},\"datePublished\":\"2021-05-21T07:53:38+00:00\",\"dateModified\":\"2023-08-31T06:18:15+00:00\",\"author\":{\"@id\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/#\/schema\/person\/ccfef987a4882e6356ae6d77d33e74c5\"},\"description\":\"Familial HDL deficiency. A genetic disease due to a mutation in the gene for the HDL protein. Characterized by very low plasma HDL and cholesterol levels, an accumulation of cholesterol esters in the tissues, and a peculiar yellow orange color to the tonsils.Tangier disease is an extremely rare autosomal recessive metabolic disorder. 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