{"id":108296,"date":"2021-05-25T07:25:53","date_gmt":"2021-05-25T07:25:53","guid":{"rendered":"https:\/\/www.healthbenefitstimes.com\/glossary\/?p=108296"},"modified":"2023-05-28T06:05:20","modified_gmt":"2023-05-28T06:05:20","slug":"alpha-1-antitrypsin-deficiency","status":"publish","type":"post","link":"https:\/\/www.healthbenefitstimes.com\/glossary\/alpha-1-antitrypsin-deficiency\/","title":{"rendered":"Alpha-1-antitrypsin deficiency"},"content":{"rendered":"<p>Alpha-1-antitrypsin deficiency (A-1-AD) is caused by an inadequate amount of the enzyme alpha- 1-antitrypsin in the blood. Affected individuals have 10-20% of normal levels of this serum protein. As a result, they experience early-onset emphysema (blebs and cysts replacing normal lung tis\u00ac sue), usually in the third or fourth decade. A-l-AD can also cause liver disease in infants and children.<\/p>\n<hr \/>\n<p>A common hereditary disorder characterized by a deficiency in levels of the blood protein alpha i-anti- trypsin (AAT). AAT is produced in the liver and inhibits the inflammatory response of the body. When AAT is deficient or absent, infection or uncontrolled inflammation can destroy tissue cells, which is seen most often in the lungs, particularly when they are exposed to cigarette smoke. Approximately 75 percent of adults with AAT deficiency who smoke will develop emphysema, a serious respiratory disease, usually before age 40.<\/p>\n<hr \/>\n<p>Alpha 1-antitrypsin (A1AT) deficiency is a hereditary condition marked by the inadequate synthesis of a crucial protein known as alpha 1-antitrypsin. This protein plays a vital role in safeguarding the flexibility and resilience of pulmonary tissue. Individuals who experience insufficiency in A1AT production face an elevated susceptibility to the development of emphysema, especially if they engage in smoking habits.<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Alpha-1-antitrypsin deficiency (A-1-AD) is caused by an inadequate amount of the enzyme alpha- 1-antitrypsin in the blood. Affected individuals have 10-20% of normal levels of this serum protein. As a result, they experience early-onset emphysema (blebs and cysts replacing normal lung tis\u00ac sue), usually in the third or fourth decade. A-l-AD can also cause liver [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-108296","post","type-post","status-publish","format-standard","hentry","category-a"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Alpha-1-antitrypsin deficiency - Definition of Alpha-1-antitrypsin deficiency<\/title>\n<meta name=\"description\" content=\"Alpha-1-antitrypsin deficiency (A-1-AD) is caused by an inadequate amount of the enzyme alpha- 1-antitrypsin in the blood. Affected individuals have 10-20% of normal levels of this serum protein. As a result, they experience early-onset emphysema (blebs and cysts replacing normal lung tis\u00ac sue), usually in the third or fourth decade. A-l-AD can also cause liver disease in infants and children.A common hereditary disorder characterized by a deficiency in levels of the blood protein alpha i-anti- trypsin (AAT). AAT is produced in the liver and inhibits the inflammatory response of the body. When AAT is deficient or absent, infection or uncontrolled inflammation can destroy tissue cells, which is seen most often in the lungs, particularly when they are exposed to cigarette smoke. Approximately 75 percent of adults with AAT deficiency who smoke will develop emphysema, a serious respiratory disease, usually before age 40.Alpha 1-antitrypsin (A1AT) deficiency is a hereditary condition marked by the inadequate synthesis of a crucial protein known as alpha 1-antitrypsin. This protein plays a vital role in safeguarding the flexibility and resilience of pulmonary tissue. Individuals who experience insufficiency in A1AT production face an elevated susceptibility to the development of emphysema, especially if they engage in smoking habits.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.healthbenefitstimes.com\/glossary\/alpha-1-antitrypsin-deficiency\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alpha-1-antitrypsin deficiency - Definition of Alpha-1-antitrypsin deficiency\" \/>\n<meta property=\"og:description\" content=\"Alpha-1-antitrypsin deficiency (A-1-AD) is caused by an inadequate amount of the enzyme alpha- 1-antitrypsin in the blood. Affected individuals have 10-20% of normal levels of this serum protein. As a result, they experience early-onset emphysema (blebs and cysts replacing normal lung tis\u00ac sue), usually in the third or fourth decade. A-l-AD can also cause liver disease in infants and children.A common hereditary disorder characterized by a deficiency in levels of the blood protein alpha i-anti- trypsin (AAT). AAT is produced in the liver and inhibits the inflammatory response of the body. When AAT is deficient or absent, infection or uncontrolled inflammation can destroy tissue cells, which is seen most often in the lungs, particularly when they are exposed to cigarette smoke. Approximately 75 percent of adults with AAT deficiency who smoke will develop emphysema, a serious respiratory disease, usually before age 40.Alpha 1-antitrypsin (A1AT) deficiency is a hereditary condition marked by the inadequate synthesis of a crucial protein known as alpha 1-antitrypsin. This protein plays a vital role in safeguarding the flexibility and resilience of pulmonary tissue. Individuals who experience insufficiency in A1AT production face an elevated susceptibility to the development of emphysema, especially if they engage in smoking habits.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.healthbenefitstimes.com\/glossary\/alpha-1-antitrypsin-deficiency\/\" \/>\n<meta property=\"og:site_name\" content=\"Glossary\" \/>\n<meta property=\"article:published_time\" content=\"2021-05-25T07:25:53+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-05-28T06:05:20+00:00\" \/>\n<meta name=\"author\" content=\"Glossary\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Glossary\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/alpha-1-antitrypsin-deficiency\/\",\"url\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/alpha-1-antitrypsin-deficiency\/\",\"name\":\"Alpha-1-antitrypsin deficiency - Definition of Alpha-1-antitrypsin deficiency\",\"isPartOf\":{\"@id\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/#website\"},\"datePublished\":\"2021-05-25T07:25:53+00:00\",\"dateModified\":\"2023-05-28T06:05:20+00:00\",\"author\":{\"@id\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/#\/schema\/person\/ccfef987a4882e6356ae6d77d33e74c5\"},\"description\":\"Alpha-1-antitrypsin deficiency (A-1-AD) is caused by an inadequate amount of the enzyme alpha- 1-antitrypsin in the blood. 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