{"id":181278,"date":"2022-09-08T06:58:45","date_gmt":"2022-09-08T06:58:45","guid":{"rendered":"https:\/\/www.healthbenefitstimes.com\/glossary\/?p=181278"},"modified":"2022-09-08T06:58:45","modified_gmt":"2022-09-08T06:58:45","slug":"ligase-chain-reaction","status":"publish","type":"post","link":"https:\/\/www.healthbenefitstimes.com\/glossary\/ligase-chain-reaction\/","title":{"rendered":"Ligase chain reaction"},"content":{"rendered":"<p>A technique for amplifying the quantity of specific sequences of nucleic acid in a specimen. The patient\u2019s DNA, or specimens thought to contain pathogenic DNA, are mixed with DNA ligase and oligonucleotide probes. Double-stranded DNA is denatured. Probes bind to the complementary strands on any denatured target DNA. Ligase joins the bound probes, and multiple copies of the DNA of interest are made. In clinical practice, ligase chain reactions are used primarily in urinary (noninvasive) assays to detect genital infections with chlamydia or gonorrhea.<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A technique for amplifying the quantity of specific sequences of nucleic acid in a specimen. The patient\u2019s DNA, or specimens thought to contain pathogenic DNA, are mixed with DNA ligase and oligonucleotide probes. Double-stranded DNA is denatured. Probes bind to the complementary strands on any denatured target DNA. Ligase joins the bound probes, and multiple [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12],"tags":[],"class_list":["post-181278","post","type-post","status-publish","format-standard","hentry","category-l"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Ligase chain reaction - Definition of Ligase chain reaction<\/title>\n<meta name=\"description\" content=\"A technique for amplifying the quantity of specific sequences of nucleic acid in a specimen. The patient\u2019s DNA, or specimens thought to contain pathogenic DNA, are mixed with DNA ligase and oligonucleotide probes. Double-stranded DNA is denatured. Probes bind to the complementary strands on any denatured target DNA. Ligase joins the bound probes, and multiple copies of the DNA of interest are made. In clinical practice, ligase chain reactions are used primarily in urinary (noninvasive) assays to detect genital infections with chlamydia or gonorrhea.\u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.healthbenefitstimes.com\/glossary\/ligase-chain-reaction\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ligase chain reaction - Definition of Ligase chain reaction\" \/>\n<meta property=\"og:description\" content=\"A technique for amplifying the quantity of specific sequences of nucleic acid in a specimen. The patient\u2019s DNA, or specimens thought to contain pathogenic DNA, are mixed with DNA ligase and oligonucleotide probes. Double-stranded DNA is denatured. Probes bind to the complementary strands on any denatured target DNA. Ligase joins the bound probes, and multiple copies of the DNA of interest are made. 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