{"id":238216,"date":"2023-08-25T07:51:38","date_gmt":"2023-08-25T07:51:38","guid":{"rendered":"https:\/\/www.healthbenefitstimes.com\/glossary\/?p=238216"},"modified":"2023-08-25T07:51:38","modified_gmt":"2023-08-25T07:51:38","slug":"pyruvate-kinase-deficiency","status":"publish","type":"post","link":"https:\/\/www.healthbenefitstimes.com\/glossary\/pyruvate-kinase-deficiency\/","title":{"rendered":"Pyruvate kinase deficiency"},"content":{"rendered":"<p>A condition characterized by unusually low levels of an enzyme called pyruvate kinase, which is present in red blood cells. Typically, pyruvate kinase facilitates the breakdown of glucose to produce energy under low-oxygen conditions. When there is a shortage of this enzyme, red blood cells become unable to generate sufficient energy for themselves. Additionally, they undergo chemical imbalances that lead to their premature destruction by the spleen, resulting in anemia and spleen enlargement. This disorder is often attributed to a defect in an autosomal recessive gene.<\/p>\n<hr \/>\n<p>The disease&#8217;s intensity varies among individuals. In many cases, treatment is unnecessary. Blood transfusions might be necessary on occasion, especially during periods of physiological strain, such as acute illness or pregnancy, when the condition tends to worsen. In severe instances, the removal of the spleen, known as splenectomy, could be advised.<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A condition characterized by unusually low levels of an enzyme called pyruvate kinase, which is present in red blood cells. Typically, pyruvate kinase facilitates the breakdown of glucose to produce energy under low-oxygen conditions. When there is a shortage of this enzyme, red blood cells become unable to generate sufficient energy for themselves. Additionally, they [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-238216","post","type-post","status-publish","format-standard","hentry","category-p"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Pyruvate kinase deficiency - Definition of Pyruvate kinase deficiency<\/title>\n<meta name=\"description\" content=\"A condition characterized by unusually low levels of an enzyme called pyruvate kinase, which is present in red blood cells. Typically, pyruvate kinase facilitates the breakdown of glucose to produce energy under low-oxygen conditions. When there is a shortage of this enzyme, red blood cells become unable to generate sufficient energy for themselves. Additionally, they undergo chemical imbalances that lead to their premature destruction by the spleen, resulting in anemia and spleen enlargement. This disorder is often attributed to a defect in an autosomal recessive gene.The disease&#039;s intensity varies among individuals. In many cases, treatment is unnecessary. Blood transfusions might be necessary on occasion, especially during periods of physiological strain, such as acute illness or pregnancy, when the condition tends to worsen. In severe instances, the removal of the spleen, known as splenectomy, could be advised.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.healthbenefitstimes.com\/glossary\/pyruvate-kinase-deficiency\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pyruvate kinase deficiency - Definition of Pyruvate kinase deficiency\" \/>\n<meta property=\"og:description\" content=\"A condition characterized by unusually low levels of an enzyme called pyruvate kinase, which is present in red blood cells. Typically, pyruvate kinase facilitates the breakdown of glucose to produce energy under low-oxygen conditions. When there is a shortage of this enzyme, red blood cells become unable to generate sufficient energy for themselves. Additionally, they undergo chemical imbalances that lead to their premature destruction by the spleen, resulting in anemia and spleen enlargement. This disorder is often attributed to a defect in an autosomal recessive gene.The disease&#039;s intensity varies among individuals. In many cases, treatment is unnecessary. Blood transfusions might be necessary on occasion, especially during periods of physiological strain, such as acute illness or pregnancy, when the condition tends to worsen. In severe instances, the removal of the spleen, known as splenectomy, could be advised.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.healthbenefitstimes.com\/glossary\/pyruvate-kinase-deficiency\/\" \/>\n<meta property=\"og:site_name\" content=\"Glossary\" \/>\n<meta property=\"article:published_time\" content=\"2023-08-25T07:51:38+00:00\" \/>\n<meta name=\"author\" content=\"Glossary\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Glossary\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/pyruvate-kinase-deficiency\/\",\"url\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/pyruvate-kinase-deficiency\/\",\"name\":\"Pyruvate kinase deficiency - Definition of Pyruvate kinase deficiency\",\"isPartOf\":{\"@id\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/#website\"},\"datePublished\":\"2023-08-25T07:51:38+00:00\",\"dateModified\":\"2023-08-25T07:51:38+00:00\",\"author\":{\"@id\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/#\/schema\/person\/ccfef987a4882e6356ae6d77d33e74c5\"},\"description\":\"A condition characterized by unusually low levels of an enzyme called pyruvate kinase, which is present in red blood cells. Typically, pyruvate kinase facilitates the breakdown of glucose to produce energy under low-oxygen conditions. When there is a shortage of this enzyme, red blood cells become unable to generate sufficient energy for themselves. Additionally, they undergo chemical imbalances that lead to their premature destruction by the spleen, resulting in anemia and spleen enlargement. This disorder is often attributed to a defect in an autosomal recessive gene.The disease's intensity varies among individuals. In many cases, treatment is unnecessary. Blood transfusions might be necessary on occasion, especially during periods of physiological strain, such as acute illness or pregnancy, when the condition tends to worsen. In severe instances, the removal of the spleen, known as splenectomy, could be advised.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/pyruvate-kinase-deficiency\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.healthbenefitstimes.com\/glossary\/pyruvate-kinase-deficiency\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/pyruvate-kinase-deficiency\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Pyruvate kinase deficiency\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/#website\",\"url\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/\",\"name\":\"Glossary\",\"description\":\"Difinitions\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/#\/schema\/person\/ccfef987a4882e6356ae6d77d33e74c5\",\"name\":\"Glossary\",\"url\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/author\/adminglossary\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Pyruvate kinase deficiency - Definition of Pyruvate kinase deficiency","description":"A condition characterized by unusually low levels of an enzyme called pyruvate kinase, which is present in red blood cells. Typically, pyruvate kinase facilitates the breakdown of glucose to produce energy under low-oxygen conditions. When there is a shortage of this enzyme, red blood cells become unable to generate sufficient energy for themselves. Additionally, they undergo chemical imbalances that lead to their premature destruction by the spleen, resulting in anemia and spleen enlargement. This disorder is often attributed to a defect in an autosomal recessive gene.The disease's intensity varies among individuals. In many cases, treatment is unnecessary. Blood transfusions might be necessary on occasion, especially during periods of physiological strain, such as acute illness or pregnancy, when the condition tends to worsen. In severe instances, the removal of the spleen, known as splenectomy, could be advised.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.healthbenefitstimes.com\/glossary\/pyruvate-kinase-deficiency\/","og_locale":"en_US","og_type":"article","og_title":"Pyruvate kinase deficiency - Definition of Pyruvate kinase deficiency","og_description":"A condition characterized by unusually low levels of an enzyme called pyruvate kinase, which is present in red blood cells. Typically, pyruvate kinase facilitates the breakdown of glucose to produce energy under low-oxygen conditions. When there is a shortage of this enzyme, red blood cells become unable to generate sufficient energy for themselves. Additionally, they undergo chemical imbalances that lead to their premature destruction by the spleen, resulting in anemia and spleen enlargement. This disorder is often attributed to a defect in an autosomal recessive gene.The disease's intensity varies among individuals. In many cases, treatment is unnecessary. Blood transfusions might be necessary on occasion, especially during periods of physiological strain, such as acute illness or pregnancy, when the condition tends to worsen. In severe instances, the removal of the spleen, known as splenectomy, could be advised.","og_url":"https:\/\/www.healthbenefitstimes.com\/glossary\/pyruvate-kinase-deficiency\/","og_site_name":"Glossary","article_published_time":"2023-08-25T07:51:38+00:00","author":"Glossary","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Glossary","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.healthbenefitstimes.com\/glossary\/pyruvate-kinase-deficiency\/","url":"https:\/\/www.healthbenefitstimes.com\/glossary\/pyruvate-kinase-deficiency\/","name":"Pyruvate kinase deficiency - Definition of Pyruvate kinase deficiency","isPartOf":{"@id":"https:\/\/www.healthbenefitstimes.com\/glossary\/#website"},"datePublished":"2023-08-25T07:51:38+00:00","dateModified":"2023-08-25T07:51:38+00:00","author":{"@id":"https:\/\/www.healthbenefitstimes.com\/glossary\/#\/schema\/person\/ccfef987a4882e6356ae6d77d33e74c5"},"description":"A condition characterized by unusually low levels of an enzyme called pyruvate kinase, which is present in red blood cells. Typically, pyruvate kinase facilitates the breakdown of glucose to produce energy under low-oxygen conditions. When there is a shortage of this enzyme, red blood cells become unable to generate sufficient energy for themselves. Additionally, they undergo chemical imbalances that lead to their premature destruction by the spleen, resulting in anemia and spleen enlargement. This disorder is often attributed to a defect in an autosomal recessive gene.The disease's intensity varies among individuals. In many cases, treatment is unnecessary. Blood transfusions might be necessary on occasion, especially during periods of physiological strain, such as acute illness or pregnancy, when the condition tends to worsen. In severe instances, the removal of the spleen, known as splenectomy, could be advised.","breadcrumb":{"@id":"https:\/\/www.healthbenefitstimes.com\/glossary\/pyruvate-kinase-deficiency\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.healthbenefitstimes.com\/glossary\/pyruvate-kinase-deficiency\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.healthbenefitstimes.com\/glossary\/pyruvate-kinase-deficiency\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.healthbenefitstimes.com\/glossary\/"},{"@type":"ListItem","position":2,"name":"Pyruvate kinase deficiency"}]},{"@type":"WebSite","@id":"https:\/\/www.healthbenefitstimes.com\/glossary\/#website","url":"https:\/\/www.healthbenefitstimes.com\/glossary\/","name":"Glossary","description":"Difinitions","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.healthbenefitstimes.com\/glossary\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.healthbenefitstimes.com\/glossary\/#\/schema\/person\/ccfef987a4882e6356ae6d77d33e74c5","name":"Glossary","url":"https:\/\/www.healthbenefitstimes.com\/glossary\/author\/adminglossary\/"}]}},"_links":{"self":[{"href":"https:\/\/www.healthbenefitstimes.com\/glossary\/wp-json\/wp\/v2\/posts\/238216","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.healthbenefitstimes.com\/glossary\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.healthbenefitstimes.com\/glossary\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.healthbenefitstimes.com\/glossary\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.healthbenefitstimes.com\/glossary\/wp-json\/wp\/v2\/comments?post=238216"}],"version-history":[{"count":1,"href":"https:\/\/www.healthbenefitstimes.com\/glossary\/wp-json\/wp\/v2\/posts\/238216\/revisions"}],"predecessor-version":[{"id":238217,"href":"https:\/\/www.healthbenefitstimes.com\/glossary\/wp-json\/wp\/v2\/posts\/238216\/revisions\/238217"}],"wp:attachment":[{"href":"https:\/\/www.healthbenefitstimes.com\/glossary\/wp-json\/wp\/v2\/media?parent=238216"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.healthbenefitstimes.com\/glossary\/wp-json\/wp\/v2\/categories?post=238216"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.healthbenefitstimes.com\/glossary\/wp-json\/wp\/v2\/tags?post=238216"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}