{"id":26324,"date":"2020-07-06T05:38:26","date_gmt":"2020-07-06T05:38:26","guid":{"rendered":"https:\/\/www.healthbenefitstimes.com\/glossary\/?p=26324"},"modified":"2020-11-11T10:30:37","modified_gmt":"2020-11-11T10:30:37","slug":"catechol-o-methyltransferase","status":"publish","type":"post","link":"https:\/\/www.healthbenefitstimes.com\/glossary\/catechol-o-methyltransferase\/","title":{"rendered":"Catechol-O-methyltransferase"},"content":{"rendered":"<p>An enzyme that degrades and inactivates catecholamines such as dopamine, epinephrine, and norepinephrine. Comt is also important in the metabolism of levodopa (l-dopa), a precursor of dopamine used in the treatment of parkinson\u2019s disease. Comt inhibitors such as entacapone (comtan) inhibit degradation of levodopa, permitting greater and more sustained levels of levodopa to penetrate the brain, where it can be converted to dopamine. Whether variations in comt contribute to susceptibility to schizophrenia is currently a matter of considerable controversy.<\/p>\n<hr \/>\n<p>Enzyme which inactivates neurotransmitters with a phenolics OH group (dopamine, nordrenaline, serotonin) through methylation.<\/p>\n<hr \/>\n<p>An enzyme that deactivates catecholamine at the synapse.<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>An enzyme that degrades and inactivates catecholamines such as dopamine, epinephrine, and norepinephrine. Comt is also important in the metabolism of levodopa (l-dopa), a precursor of dopamine used in the treatment of parkinson\u2019s disease. Comt inhibitors such as entacapone (comtan) inhibit degradation of levodopa, permitting greater and more sustained levels of levodopa to penetrate the [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-26324","post","type-post","status-publish","format-standard","hentry","category-c"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Catechol-O-methyltransferase - Definition of Catechol-O-methyltransferase<\/title>\n<meta name=\"description\" content=\"An enzyme that degrades and inactivates catecholamines such as dopamine, epinephrine, and norepinephrine. Comt is also important in the metabolism of levodopa (l-dopa), a precursor of dopamine used in the treatment of parkinson\u2019s disease. Comt inhibitors such as entacapone (comtan) inhibit degradation of levodopa, permitting greater and more sustained levels of levodopa to penetrate the brain, where it can be converted to dopamine. Whether variations in comt contribute to susceptibility to schizophrenia is currently a matter of considerable controversy.Enzyme which inactivates neurotransmitters with a phenolics OH group (dopamine, nordrenaline, serotonin) through methylation.An enzyme that deactivates catecholamine at the synapse.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.healthbenefitstimes.com\/glossary\/catechol-o-methyltransferase\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Catechol-O-methyltransferase - Definition of Catechol-O-methyltransferase\" \/>\n<meta property=\"og:description\" content=\"An enzyme that degrades and inactivates catecholamines such as dopamine, epinephrine, and norepinephrine. Comt is also important in the metabolism of levodopa (l-dopa), a precursor of dopamine used in the treatment of parkinson\u2019s disease. Comt inhibitors such as entacapone (comtan) inhibit degradation of levodopa, permitting greater and more sustained levels of levodopa to penetrate the brain, where it can be converted to dopamine. Whether variations in comt contribute to susceptibility to schizophrenia is currently a matter of considerable controversy.Enzyme which inactivates neurotransmitters with a phenolics OH group (dopamine, nordrenaline, serotonin) through methylation.An enzyme that deactivates catecholamine at the synapse.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.healthbenefitstimes.com\/glossary\/catechol-o-methyltransferase\/\" \/>\n<meta property=\"og:site_name\" content=\"Glossary\" \/>\n<meta property=\"article:published_time\" content=\"2020-07-06T05:38:26+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-11-11T10:30:37+00:00\" \/>\n<meta name=\"author\" content=\"Glossary\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Glossary\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/catechol-o-methyltransferase\/\",\"url\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/catechol-o-methyltransferase\/\",\"name\":\"Catechol-O-methyltransferase - Definition of Catechol-O-methyltransferase\",\"isPartOf\":{\"@id\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/#website\"},\"datePublished\":\"2020-07-06T05:38:26+00:00\",\"dateModified\":\"2020-11-11T10:30:37+00:00\",\"author\":{\"@id\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/#\/schema\/person\/ccfef987a4882e6356ae6d77d33e74c5\"},\"description\":\"An enzyme that degrades and inactivates catecholamines such as dopamine, epinephrine, and norepinephrine. 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