{"id":31771,"date":"2020-07-24T07:49:41","date_gmt":"2020-07-24T07:49:41","guid":{"rendered":"https:\/\/www.healthbenefitstimes.com\/glossary\/?p=31771"},"modified":"2020-07-24T07:49:41","modified_gmt":"2020-07-24T07:49:41","slug":"phase-i-metabolism-reactions","status":"publish","type":"post","link":"https:\/\/www.healthbenefitstimes.com\/glossary\/phase-i-metabolism-reactions\/","title":{"rendered":"Phase I metabolism reactions"},"content":{"rendered":"<p>The first phase of metabolism of foreign compounds (xenobiotics), involving metabolic activation. These reactions occur mainly in the liver but also in the small intestine and lungs and comprise the microsomal or mixed function oxidase system, NADPH- dependent enzymes and cytochrome P450 proteins. Generally regarded as detoxication reactions, but may in fact convert inactive precursors into metabolically active compounds, and be involved in activation of precursors to carcinogens.<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The first phase of metabolism of foreign compounds (xenobiotics), involving metabolic activation. These reactions occur mainly in the liver but also in the small intestine and lungs and comprise the microsomal or mixed function oxidase system, NADPH- dependent enzymes and cytochrome P450 proteins. Generally regarded as detoxication reactions, but may in fact convert inactive precursors [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-31771","post","type-post","status-publish","format-standard","hentry","category-p"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Phase I metabolism reactions - Definition of Phase I metabolism reactions<\/title>\n<meta name=\"description\" content=\"The first phase of metabolism of foreign compounds (xenobiotics), involving metabolic activation. These reactions occur mainly in the liver but also in the small intestine and lungs and comprise the microsomal or mixed function oxidase system, NADPH- dependent enzymes and cytochrome P450 proteins. 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