{"id":37954,"date":"2020-08-18T06:14:28","date_gmt":"2020-08-18T06:14:28","guid":{"rendered":"https:\/\/www.healthbenefitstimes.com\/glossary\/?p=37954"},"modified":"2020-08-18T06:14:28","modified_gmt":"2020-08-18T06:14:28","slug":"gene-delivery-gene-therapy","status":"publish","type":"post","link":"https:\/\/www.healthbenefitstimes.com\/glossary\/gene-delivery-gene-therapy\/","title":{"rendered":"Gene delivery (gene therapy)"},"content":{"rendered":"<p>The insertion of genes (e.g., via retroviral vectors) into selected cells in the body in order to:<\/p>\n<ul>\n<li>cause those cells to produce specific therapeutic agents (e.g., growth hormone in livestock, factor VIII in hemophiliacs, insulin in diabetics, etc.). A potential way of curing some genetic diseases, in that the inserted gene will produce the protein and\/or enzyme that is missing in the body due to a defective gene (thus causing the genetic disease). Approximately 3,000 genetic diseases are known to man. Examples of genetic diseases include cystic fibrosis, sickle cell anemia, Huntington&#8217;s disease, phenylketonuria (PKU), Tay-Sach&#8217;s disease, ADA deficiency (adenosine deaminase enzyme deficiency) and thalassemia.<\/li>\n<li>cause those cells to become (more) susceptible to a conventional therapeutic agent that previously was ineffective against that particular condition\/disease (e.g., insertion of Hs-tk gene into brain tumor cells to make those tumor cells susceptible to the Syntex drug Ganciclovir)<\/li>\n<li>cause those cells to become less susceptible to a conventional therapeutic agent (e.g., insert genes into healthy tissue in order to enable that healthy tissue to resist the harmful effects of such conventional chemotherapy agents as vincristine)<\/li>\n<li>counter the effects of abnormal (damaged) tumor suppressor genes via insertion of normal tumor suppressor genes<\/li>\n<li>cause expression of ribozymes that cleave oncogenes (cancer-causing genes)<\/li>\n<li>be used for other therapeutic uses of genes in cells.<\/li>\n<\/ul>\n<hr \/>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The insertion of genes (e.g., via retroviral vectors) into selected cells in the body in order to: cause those cells to produce specific therapeutic agents (e.g., growth hormone in livestock, factor VIII in hemophiliacs, insulin in diabetics, etc.). A potential way of curing some genetic diseases, in that the inserted gene will produce the protein [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-37954","post","type-post","status-publish","format-standard","hentry","category-g"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Gene delivery (gene therapy) - Definition of Gene delivery (gene therapy)<\/title>\n<meta name=\"description\" content=\"The insertion of genes (e.g., via retroviral vectors) into selected cells in the body in order to:cause those cells to produce specific therapeutic agents (e.g., growth hormone in livestock, factor VIII in hemophiliacs, insulin in diabetics, etc.). A potential way of curing some genetic diseases, in that the inserted gene will produce the protein and\/or enzyme that is missing in the body due to a defective gene (thus causing the genetic disease). Approximately 3,000 genetic diseases are known to man. Examples of genetic diseases include cystic fibrosis, sickle cell anemia, Huntington&#039;s disease, phenylketonuria (PKU), Tay-Sach&#039;s disease, ADA deficiency (adenosine deaminase enzyme deficiency) and thalassemia.cause those cells to become (more) susceptible to a conventional therapeutic agent that previously was ineffective against that particular condition\/disease (e.g., insertion of Hs-tk gene into brain tumor cells to make those tumor cells susceptible to the Syntex drug Ganciclovir)cause those cells to become less susceptible to a conventional therapeutic agent (e.g., insert genes into healthy tissue in order to enable that healthy tissue to resist the harmful effects of such conventional chemotherapy agents as vincristine)counter the effects of abnormal (damaged) tumor suppressor genes via insertion of normal tumor suppressor genescause expression of ribozymes that cleave oncogenes (cancer-causing genes)be used for other therapeutic uses of genes in cells.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.healthbenefitstimes.com\/glossary\/gene-delivery-gene-therapy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gene delivery (gene therapy) - Definition of Gene delivery (gene therapy)\" \/>\n<meta property=\"og:description\" content=\"The insertion of genes (e.g., via retroviral vectors) into selected cells in the body in order to:cause those cells to produce specific therapeutic agents (e.g., growth hormone in livestock, factor VIII in hemophiliacs, insulin in diabetics, etc.). 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