{"id":39333,"date":"2020-09-08T08:31:33","date_gmt":"2020-09-08T08:31:33","guid":{"rendered":"https:\/\/www.healthbenefitstimes.com\/glossary\/?p=39333"},"modified":"2023-01-03T08:10:55","modified_gmt":"2023-01-03T08:10:55","slug":"substance-p","status":"publish","type":"post","link":"https:\/\/www.healthbenefitstimes.com\/glossary\/substance-p\/","title":{"rendered":"Substance P"},"content":{"rendered":"<p>A neuropeptide (i.e., peptide produced by cells of the nervous system) which is involved in activation of the immune system, pain sensation, and (when in excess) some psychiatric disorders. In the case of chronic, intractable pain (hypersensitivity), approximately one percent of the nerve cells in the human spine process substance P (thereby &#8220;transmitting&#8221; its pain message via signal transduction). In 1997, Patrick Mantyh showed that killing those (one percent) cells relieved chronic pain hypersensitivity without impairing sense of touch or normal (beneficial) pain sensation, in humans.<\/p>\n<hr \/>\n<p>A peptide found in nerves that transmits pain signals.<\/p>\n<hr \/>\n<p>An 11-amino acid peptide that has important functions in the body\u2019s response to pain, noxious stimuli, depression, and anxiety. This substance may also be important in eliciting local tissue reactions resembling inflammation.<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A neuropeptide (i.e., peptide produced by cells of the nervous system) which is involved in activation of the immune system, pain sensation, and (when in excess) some psychiatric disorders. In the case of chronic, intractable pain (hypersensitivity), approximately one percent of the nerve cells in the human spine process substance P (thereby &#8220;transmitting&#8221; its pain [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[19],"tags":[],"class_list":["post-39333","post","type-post","status-publish","format-standard","hentry","category-s"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Substance P - Definition of Substance P<\/title>\n<meta name=\"description\" content=\"A neuropeptide (i.e., peptide produced by cells of the nervous system) which is involved in activation of the immune system, pain sensation, and (when in excess) some psychiatric disorders. In the case of chronic, intractable pain (hypersensitivity), approximately one percent of the nerve cells in the human spine process substance P (thereby &quot;transmitting&quot; its pain message via signal transduction). In 1997, Patrick Mantyh showed that killing those (one percent) cells relieved chronic pain hypersensitivity without impairing sense of touch or normal (beneficial) pain sensation, in humans.A peptide found in nerves that transmits pain signals.An 11-amino acid peptide that has important functions in the body\u2019s response to pain, noxious stimuli, depression, and anxiety. This substance may also be important in eliciting local tissue reactions resembling inflammation.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.healthbenefitstimes.com\/glossary\/substance-p\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Substance P - Definition of Substance P\" \/>\n<meta property=\"og:description\" content=\"A neuropeptide (i.e., peptide produced by cells of the nervous system) which is involved in activation of the immune system, pain sensation, and (when in excess) some psychiatric disorders. In the case of chronic, intractable pain (hypersensitivity), approximately one percent of the nerve cells in the human spine process substance P (thereby &quot;transmitting&quot; its pain message via signal transduction). In 1997, Patrick Mantyh showed that killing those (one percent) cells relieved chronic pain hypersensitivity without impairing sense of touch or normal (beneficial) pain sensation, in humans.A peptide found in nerves that transmits pain signals.An 11-amino acid peptide that has important functions in the body\u2019s response to pain, noxious stimuli, depression, and anxiety. This substance may also be important in eliciting local tissue reactions resembling inflammation.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.healthbenefitstimes.com\/glossary\/substance-p\/\" \/>\n<meta property=\"og:site_name\" content=\"Glossary\" \/>\n<meta property=\"article:published_time\" content=\"2020-09-08T08:31:33+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-01-03T08:10:55+00:00\" \/>\n<meta name=\"author\" content=\"Glossary\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Glossary\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/substance-p\/\",\"url\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/substance-p\/\",\"name\":\"Substance P - Definition of Substance P\",\"isPartOf\":{\"@id\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/#website\"},\"datePublished\":\"2020-09-08T08:31:33+00:00\",\"dateModified\":\"2023-01-03T08:10:55+00:00\",\"author\":{\"@id\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/#\/schema\/person\/ccfef987a4882e6356ae6d77d33e74c5\"},\"description\":\"A neuropeptide (i.e., peptide produced by cells of the nervous system) which is involved in activation of the immune system, pain sensation, and (when in excess) some psychiatric disorders. In the case of chronic, intractable pain (hypersensitivity), approximately one percent of the nerve cells in the human spine process substance P (thereby \\\"transmitting\\\" its pain message via signal transduction). In 1997, Patrick Mantyh showed that killing those (one percent) cells relieved chronic pain hypersensitivity without impairing sense of touch or normal (beneficial) pain sensation, in humans.A peptide found in nerves that transmits pain signals.An 11-amino acid peptide that has important functions in the body\u2019s response to pain, noxious stimuli, depression, and anxiety. This substance may also be important in eliciting local tissue reactions resembling inflammation.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/substance-p\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.healthbenefitstimes.com\/glossary\/substance-p\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/substance-p\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Substance P\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/#website\",\"url\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/\",\"name\":\"Glossary\",\"description\":\"Difinitions\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/#\/schema\/person\/ccfef987a4882e6356ae6d77d33e74c5\",\"name\":\"Glossary\",\"url\":\"https:\/\/www.healthbenefitstimes.com\/glossary\/author\/adminglossary\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Substance P - Definition of Substance P","description":"A neuropeptide (i.e., peptide produced by cells of the nervous system) which is involved in activation of the immune system, pain sensation, and (when in excess) some psychiatric disorders. In the case of chronic, intractable pain (hypersensitivity), approximately one percent of the nerve cells in the human spine process substance P (thereby \"transmitting\" its pain message via signal transduction). In 1997, Patrick Mantyh showed that killing those (one percent) cells relieved chronic pain hypersensitivity without impairing sense of touch or normal (beneficial) pain sensation, in humans.A peptide found in nerves that transmits pain signals.An 11-amino acid peptide that has important functions in the body\u2019s response to pain, noxious stimuli, depression, and anxiety. This substance may also be important in eliciting local tissue reactions resembling inflammation.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.healthbenefitstimes.com\/glossary\/substance-p\/","og_locale":"en_US","og_type":"article","og_title":"Substance P - Definition of Substance P","og_description":"A neuropeptide (i.e., peptide produced by cells of the nervous system) which is involved in activation of the immune system, pain sensation, and (when in excess) some psychiatric disorders. In the case of chronic, intractable pain (hypersensitivity), approximately one percent of the nerve cells in the human spine process substance P (thereby \"transmitting\" its pain message via signal transduction). In 1997, Patrick Mantyh showed that killing those (one percent) cells relieved chronic pain hypersensitivity without impairing sense of touch or normal (beneficial) pain sensation, in humans.A peptide found in nerves that transmits pain signals.An 11-amino acid peptide that has important functions in the body\u2019s response to pain, noxious stimuli, depression, and anxiety. This substance may also be important in eliciting local tissue reactions resembling inflammation.","og_url":"https:\/\/www.healthbenefitstimes.com\/glossary\/substance-p\/","og_site_name":"Glossary","article_published_time":"2020-09-08T08:31:33+00:00","article_modified_time":"2023-01-03T08:10:55+00:00","author":"Glossary","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Glossary","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.healthbenefitstimes.com\/glossary\/substance-p\/","url":"https:\/\/www.healthbenefitstimes.com\/glossary\/substance-p\/","name":"Substance P - Definition of Substance P","isPartOf":{"@id":"https:\/\/www.healthbenefitstimes.com\/glossary\/#website"},"datePublished":"2020-09-08T08:31:33+00:00","dateModified":"2023-01-03T08:10:55+00:00","author":{"@id":"https:\/\/www.healthbenefitstimes.com\/glossary\/#\/schema\/person\/ccfef987a4882e6356ae6d77d33e74c5"},"description":"A neuropeptide (i.e., peptide produced by cells of the nervous system) which is involved in activation of the immune system, pain sensation, and (when in excess) some psychiatric disorders. In the case of chronic, intractable pain (hypersensitivity), approximately one percent of the nerve cells in the human spine process substance P (thereby \"transmitting\" its pain message via signal transduction). In 1997, Patrick Mantyh showed that killing those (one percent) cells relieved chronic pain hypersensitivity without impairing sense of touch or normal (beneficial) pain sensation, in humans.A peptide found in nerves that transmits pain signals.An 11-amino acid peptide that has important functions in the body\u2019s response to pain, noxious stimuli, depression, and anxiety. This substance may also be important in eliciting local tissue reactions resembling inflammation.","breadcrumb":{"@id":"https:\/\/www.healthbenefitstimes.com\/glossary\/substance-p\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.healthbenefitstimes.com\/glossary\/substance-p\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.healthbenefitstimes.com\/glossary\/substance-p\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.healthbenefitstimes.com\/glossary\/"},{"@type":"ListItem","position":2,"name":"Substance P"}]},{"@type":"WebSite","@id":"https:\/\/www.healthbenefitstimes.com\/glossary\/#website","url":"https:\/\/www.healthbenefitstimes.com\/glossary\/","name":"Glossary","description":"Difinitions","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.healthbenefitstimes.com\/glossary\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.healthbenefitstimes.com\/glossary\/#\/schema\/person\/ccfef987a4882e6356ae6d77d33e74c5","name":"Glossary","url":"https:\/\/www.healthbenefitstimes.com\/glossary\/author\/adminglossary\/"}]}},"_links":{"self":[{"href":"https:\/\/www.healthbenefitstimes.com\/glossary\/wp-json\/wp\/v2\/posts\/39333","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.healthbenefitstimes.com\/glossary\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.healthbenefitstimes.com\/glossary\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.healthbenefitstimes.com\/glossary\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.healthbenefitstimes.com\/glossary\/wp-json\/wp\/v2\/comments?post=39333"}],"version-history":[{"count":3,"href":"https:\/\/www.healthbenefitstimes.com\/glossary\/wp-json\/wp\/v2\/posts\/39333\/revisions"}],"predecessor-version":[{"id":202750,"href":"https:\/\/www.healthbenefitstimes.com\/glossary\/wp-json\/wp\/v2\/posts\/39333\/revisions\/202750"}],"wp:attachment":[{"href":"https:\/\/www.healthbenefitstimes.com\/glossary\/wp-json\/wp\/v2\/media?parent=39333"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.healthbenefitstimes.com\/glossary\/wp-json\/wp\/v2\/categories?post=39333"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.healthbenefitstimes.com\/glossary\/wp-json\/wp\/v2\/tags?post=39333"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}